Role of the BCR complex in B cell development, activation, and leukemic transformation

Susan R. Rheingold, Valerie I. Brown, Junjie Fang, Jenny M. Kim, Stephan A. Grupp

Research output: Contribution to journalReview article

1 Scopus citations

Abstract

A primary focus of signal transduction in B cells, from the pre-B cell to the mature B cell, is the B cell receptor complex. Here we describe work demonstrating the importance of signaling via the pre-B cell receptor complex (pre-BCR) to the pre-B cell transition, the central checkpoint in B-cell development. We have shown tht pre-BCR complex components Igα and Igβ are critical to allowing the pre-B cell to move through this transition, but may not be required for allelic exclusion. Pre-BCR expression also directly affects the response of leukemic cells to steroid treatment, suggesting that signals initiated by the pre-BCR complex may present therapeutic targets in acute leukemia. Additionally, interleukin-7 may also modulate the response of leukemic cells arising from early B-cell stages to treatment. This observation has lead directly to proposals to test drugs which may antagonize early B-cell growth signals, such as rapamycin, in acute lymphoid leukemia.

Original languageEnglish (US)
Pages (from-to)309-329
Number of pages21
JournalImmunologic Research
Volume27
Issue number2-3
DOIs
StatePublished - Aug 28 2003

All Science Journal Classification (ASJC) codes

  • Immunology

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