Role of the parabrachial nuclei in the airway dilation evoked by the Hering-Breuer reflex

Ann M. Motekaitis, Irene C. Solomon, Marc P. Kaufman

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

We tested the hypothesis that blockade of glutamatergic receptors in the parabrachial nucleus (PBN) of chloralose-anesthetized cats attenuated the reflex airway dilation evoked by activation of pulmonary stretch receptors. Unilateral microinjection of kynurenic acid (50 nl, 100 mM) into the PBN reversibly attenuated the reflex relaxation of the trachealis muscle in 7 cats. These findings suggest that the PBN is part of the central pathway mediating the airway dilation component of the Hering-Breuer reflex.

Original languageEnglish (US)
Pages (from-to)314-316
Number of pages3
JournalBrain research
Volume671
Issue number2
DOIs
StatePublished - Feb 13 1995

Fingerprint

Reflex
Dilatation
Cats
Pulmonary Stretch Receptors
Kynurenic Acid
Chloralose
Muscle Relaxation
Microinjections
Parabrachial Nucleus

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Cite this

Motekaitis, Ann M. ; Solomon, Irene C. ; Kaufman, Marc P. / Role of the parabrachial nuclei in the airway dilation evoked by the Hering-Breuer reflex. In: Brain research. 1995 ; Vol. 671, No. 2. pp. 314-316.
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Role of the parabrachial nuclei in the airway dilation evoked by the Hering-Breuer reflex. / Motekaitis, Ann M.; Solomon, Irene C.; Kaufman, Marc P.

In: Brain research, Vol. 671, No. 2, 13.02.1995, p. 314-316.

Research output: Contribution to journalArticle

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