S-emopamil ameliorates ischemic brain damage in rats

Histological and behavioural approaches

F. Block, R. M A Jaspers, Christine Marcelle Heim, K. H. Sontag

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Transient ischemia induced by 4 vessel occlusion (4VO) in rats is known to produce neuronal damage to particular brain structures such as the CAl sector of the hippocampus. Behavioural changes associated with ischemic lesioning of this brain region are an impairment in spatial learning of rats tested in a water maze (14). In the present study, it was investigated whether pretreatment with S-emopamil, a Ca2+-channel blocker as well as a 5-HT2 antagonist, prevents the occurence of hippocampal cell damage and/or spatial learning impairments in rats subjected to 4VO. Neuronal lesioning in the hippocampus was significantly reduced following pretreatment with S-emopamil in 4VO rats. In addition, S-emopamil treated animals showed an improved spatial learning ability compared to saline treated 4VO rats. It is suggested that S-emopamil may exert a protective effect under ischemic conditions. The possible mechanisms involved are discussed.

Original languageEnglish (US)
Pages (from-to)1511-1518
Number of pages8
JournalLife Sciences
Volume47
Issue number17
DOIs
StatePublished - Jan 1 1990

Fingerprint

Rats
Brain
Hippocampus
Serotonin 5-HT2 Receptor Antagonists
Animals
Ischemia
Cells
emopamil
Water
Spatial Learning

All Science Journal Classification (ASJC) codes

  • Pharmacology

Cite this

Block, F. ; Jaspers, R. M A ; Heim, Christine Marcelle ; Sontag, K. H. / S-emopamil ameliorates ischemic brain damage in rats : Histological and behavioural approaches. In: Life Sciences. 1990 ; Vol. 47, No. 17. pp. 1511-1518.
@article{62fb0b8bdbc64e14b38aeb730c4f597a,
title = "S-emopamil ameliorates ischemic brain damage in rats: Histological and behavioural approaches",
abstract = "Transient ischemia induced by 4 vessel occlusion (4VO) in rats is known to produce neuronal damage to particular brain structures such as the CAl sector of the hippocampus. Behavioural changes associated with ischemic lesioning of this brain region are an impairment in spatial learning of rats tested in a water maze (14). In the present study, it was investigated whether pretreatment with S-emopamil, a Ca2+-channel blocker as well as a 5-HT2 antagonist, prevents the occurence of hippocampal cell damage and/or spatial learning impairments in rats subjected to 4VO. Neuronal lesioning in the hippocampus was significantly reduced following pretreatment with S-emopamil in 4VO rats. In addition, S-emopamil treated animals showed an improved spatial learning ability compared to saline treated 4VO rats. It is suggested that S-emopamil may exert a protective effect under ischemic conditions. The possible mechanisms involved are discussed.",
author = "F. Block and Jaspers, {R. M A} and Heim, {Christine Marcelle} and Sontag, {K. H.}",
year = "1990",
month = "1",
day = "1",
doi = "10.1016/0024-3205(90)90179-U",
language = "English (US)",
volume = "47",
pages = "1511--1518",
journal = "Life Sciences",
issn = "0024-3205",
publisher = "Elsevier Inc.",
number = "17",

}

S-emopamil ameliorates ischemic brain damage in rats : Histological and behavioural approaches. / Block, F.; Jaspers, R. M A; Heim, Christine Marcelle; Sontag, K. H.

In: Life Sciences, Vol. 47, No. 17, 01.01.1990, p. 1511-1518.

Research output: Contribution to journalArticle

TY - JOUR

T1 - S-emopamil ameliorates ischemic brain damage in rats

T2 - Histological and behavioural approaches

AU - Block, F.

AU - Jaspers, R. M A

AU - Heim, Christine Marcelle

AU - Sontag, K. H.

PY - 1990/1/1

Y1 - 1990/1/1

N2 - Transient ischemia induced by 4 vessel occlusion (4VO) in rats is known to produce neuronal damage to particular brain structures such as the CAl sector of the hippocampus. Behavioural changes associated with ischemic lesioning of this brain region are an impairment in spatial learning of rats tested in a water maze (14). In the present study, it was investigated whether pretreatment with S-emopamil, a Ca2+-channel blocker as well as a 5-HT2 antagonist, prevents the occurence of hippocampal cell damage and/or spatial learning impairments in rats subjected to 4VO. Neuronal lesioning in the hippocampus was significantly reduced following pretreatment with S-emopamil in 4VO rats. In addition, S-emopamil treated animals showed an improved spatial learning ability compared to saline treated 4VO rats. It is suggested that S-emopamil may exert a protective effect under ischemic conditions. The possible mechanisms involved are discussed.

AB - Transient ischemia induced by 4 vessel occlusion (4VO) in rats is known to produce neuronal damage to particular brain structures such as the CAl sector of the hippocampus. Behavioural changes associated with ischemic lesioning of this brain region are an impairment in spatial learning of rats tested in a water maze (14). In the present study, it was investigated whether pretreatment with S-emopamil, a Ca2+-channel blocker as well as a 5-HT2 antagonist, prevents the occurence of hippocampal cell damage and/or spatial learning impairments in rats subjected to 4VO. Neuronal lesioning in the hippocampus was significantly reduced following pretreatment with S-emopamil in 4VO rats. In addition, S-emopamil treated animals showed an improved spatial learning ability compared to saline treated 4VO rats. It is suggested that S-emopamil may exert a protective effect under ischemic conditions. The possible mechanisms involved are discussed.

UR - http://www.scopus.com/inward/record.url?scp=0025252451&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025252451&partnerID=8YFLogxK

U2 - 10.1016/0024-3205(90)90179-U

DO - 10.1016/0024-3205(90)90179-U

M3 - Article

VL - 47

SP - 1511

EP - 1518

JO - Life Sciences

JF - Life Sciences

SN - 0024-3205

IS - 17

ER -