Safety Assessment of 1,2-Glycols as Used in Cosmetics

Wilbur Johnson, Wilma F. Bergfeld, Donald V. Belsito, Ronald A. Hill, Curtis D. Klaassen, Daniel Liebler, James Marks, Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder, F. Alan Andersen

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Caprylyl glycol and related 1,2-glycols are used mostly as skin and hair conditioning agents and viscosity agents in cosmetic products, and caprylyl glycol and pentylene glycol also function as cosmetic preservatives. The Cosmetic Ingredient Review (CIR) Expert Panel noted that, while these ingredients are dermally absorbed, modeling data predicted decreased skin penetration of longer chain 1,2-glycols. Because the negative oral toxicity data on shorter chain 1,2-glycols and genotoxicity data support the safety of the 1,2-glycols reviewed in this safety assessment, the Panel concluded that these ingredients are safe in the present practices of use and concentration described in this safety assessment.

Original languageEnglish (US)
Pages (from-to)147S-168S
JournalInternational journal of toxicology
Volume31
DOIs
StatePublished - Jan 1 2012

Fingerprint

Glycols
Cosmetics
Safety
Skin
Viscosity
Hair
Toxicity
Data structures
1,2-octanediol

All Science Journal Classification (ASJC) codes

  • Toxicology

Cite this

Johnson, W., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., Liebler, D., ... Andersen, F. A. (2012). Safety Assessment of 1,2-Glycols as Used in Cosmetics. International journal of toxicology, 31, 147S-168S. https://doi.org/10.1177/1091581812460409
Johnson, Wilbur ; Bergfeld, Wilma F. ; Belsito, Donald V. ; Hill, Ronald A. ; Klaassen, Curtis D. ; Liebler, Daniel ; Marks, James ; Shank, Ronald C. ; Slaga, Thomas J. ; Snyder, Paul W. ; Andersen, F. Alan. / Safety Assessment of 1,2-Glycols as Used in Cosmetics. In: International journal of toxicology. 2012 ; Vol. 31. pp. 147S-168S.
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Johnson, W, Bergfeld, WF, Belsito, DV, Hill, RA, Klaassen, CD, Liebler, D, Marks, J, Shank, RC, Slaga, TJ, Snyder, PW & Andersen, FA 2012, 'Safety Assessment of 1,2-Glycols as Used in Cosmetics', International journal of toxicology, vol. 31, pp. 147S-168S. https://doi.org/10.1177/1091581812460409

Safety Assessment of 1,2-Glycols as Used in Cosmetics. / Johnson, Wilbur; Bergfeld, Wilma F.; Belsito, Donald V.; Hill, Ronald A.; Klaassen, Curtis D.; Liebler, Daniel; Marks, James; Shank, Ronald C.; Slaga, Thomas J.; Snyder, Paul W.; Andersen, F. Alan.

In: International journal of toxicology, Vol. 31, 01.01.2012, p. 147S-168S.

Research output: Contribution to journalArticle

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Johnson W, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler D et al. Safety Assessment of 1,2-Glycols as Used in Cosmetics. International journal of toxicology. 2012 Jan 1;31:147S-168S. https://doi.org/10.1177/1091581812460409