Safety Assessment of Achillea millefolium as Used in Cosmetics

Lillian C. Becker, Wilma F. Bergfeld, Donald V. Belsito, Ronald A. Hill, Curtis D. Klaassen, Daniel C. Liebler, James Marks, Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder, F. Alan Andersen, Lillian J. Gill

Research output: Contribution to journalArticle

Abstract

Cosmetic ingredients derived from Achillea millefolium function in cosmetics as skin-conditioning agents - miscellaneous, skin-conditioning agents - humectants, and fragrance ingredients. The Cosmetic Ingredient Review Expert Panel (Panel) reviewed relevant animal and human data to determine their safety in cosmetics and raised concerns about cosmetics containing linalool, thujone, quercetin, hydroquinone, or α-peroxyachifolid. Because final product formulations may contain multiple botanicals, each containing similar constituents of concern, formulators are advised to be aware of these components and to avoid reaching levels that may be hazardous to consumers. Additionally, industry was advised to use good manufacturing practices to limit impurities. The Panel concluded that achillea millefolium extract, achillea millefolium flower extract, and achillea millefolium flower/leaf/stem extract are safe in the present practices of use and concentration in cosmetics when formulated to be nonsensitizing.

Original languageEnglish (US)
Pages (from-to)5S-15S
JournalInternational Journal of Toxicology
Volume35
Issue number3_suppl
DOIs
StatePublished - Nov 1 2016

Fingerprint

Achillea
Cosmetics
Safety
Skin
Hygroscopic Agents
Fragrances
Quercetin
Industry
Animals
Impurities

All Science Journal Classification (ASJC) codes

  • Toxicology

Cite this

Becker, L. C., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., Liebler, D. C., ... Gill, L. J. (2016). Safety Assessment of Achillea millefolium as Used in Cosmetics. International Journal of Toxicology, 35(3_suppl), 5S-15S. https://doi.org/10.1177/1091581816677717
Becker, Lillian C. ; Bergfeld, Wilma F. ; Belsito, Donald V. ; Hill, Ronald A. ; Klaassen, Curtis D. ; Liebler, Daniel C. ; Marks, James ; Shank, Ronald C. ; Slaga, Thomas J. ; Snyder, Paul W. ; Andersen, F. Alan ; Gill, Lillian J. / Safety Assessment of Achillea millefolium as Used in Cosmetics. In: International Journal of Toxicology. 2016 ; Vol. 35, No. 3_suppl. pp. 5S-15S.
@article{b0e4e99679c74dd6b6346250aea9eb7c,
title = "Safety Assessment of Achillea millefolium as Used in Cosmetics",
abstract = "Cosmetic ingredients derived from Achillea millefolium function in cosmetics as skin-conditioning agents - miscellaneous, skin-conditioning agents - humectants, and fragrance ingredients. The Cosmetic Ingredient Review Expert Panel (Panel) reviewed relevant animal and human data to determine their safety in cosmetics and raised concerns about cosmetics containing linalool, thujone, quercetin, hydroquinone, or α-peroxyachifolid. Because final product formulations may contain multiple botanicals, each containing similar constituents of concern, formulators are advised to be aware of these components and to avoid reaching levels that may be hazardous to consumers. Additionally, industry was advised to use good manufacturing practices to limit impurities. The Panel concluded that achillea millefolium extract, achillea millefolium flower extract, and achillea millefolium flower/leaf/stem extract are safe in the present practices of use and concentration in cosmetics when formulated to be nonsensitizing.",
author = "Becker, {Lillian C.} and Bergfeld, {Wilma F.} and Belsito, {Donald V.} and Hill, {Ronald A.} and Klaassen, {Curtis D.} and Liebler, {Daniel C.} and James Marks and Shank, {Ronald C.} and Slaga, {Thomas J.} and Snyder, {Paul W.} and Andersen, {F. Alan} and Gill, {Lillian J.}",
year = "2016",
month = "11",
day = "1",
doi = "10.1177/1091581816677717",
language = "English (US)",
volume = "35",
pages = "5S--15S",
journal = "International Journal of Toxicology",
issn = "1091-5818",
publisher = "SAGE Publications Inc.",
number = "3_suppl",

}

Becker, LC, Bergfeld, WF, Belsito, DV, Hill, RA, Klaassen, CD, Liebler, DC, Marks, J, Shank, RC, Slaga, TJ, Snyder, PW, Andersen, FA & Gill, LJ 2016, 'Safety Assessment of Achillea millefolium as Used in Cosmetics', International Journal of Toxicology, vol. 35, no. 3_suppl, pp. 5S-15S. https://doi.org/10.1177/1091581816677717

Safety Assessment of Achillea millefolium as Used in Cosmetics. / Becker, Lillian C.; Bergfeld, Wilma F.; Belsito, Donald V.; Hill, Ronald A.; Klaassen, Curtis D.; Liebler, Daniel C.; Marks, James; Shank, Ronald C.; Slaga, Thomas J.; Snyder, Paul W.; Andersen, F. Alan; Gill, Lillian J.

In: International Journal of Toxicology, Vol. 35, No. 3_suppl, 01.11.2016, p. 5S-15S.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Safety Assessment of Achillea millefolium as Used in Cosmetics

AU - Becker, Lillian C.

AU - Bergfeld, Wilma F.

AU - Belsito, Donald V.

AU - Hill, Ronald A.

AU - Klaassen, Curtis D.

AU - Liebler, Daniel C.

AU - Marks, James

AU - Shank, Ronald C.

AU - Slaga, Thomas J.

AU - Snyder, Paul W.

AU - Andersen, F. Alan

AU - Gill, Lillian J.

PY - 2016/11/1

Y1 - 2016/11/1

N2 - Cosmetic ingredients derived from Achillea millefolium function in cosmetics as skin-conditioning agents - miscellaneous, skin-conditioning agents - humectants, and fragrance ingredients. The Cosmetic Ingredient Review Expert Panel (Panel) reviewed relevant animal and human data to determine their safety in cosmetics and raised concerns about cosmetics containing linalool, thujone, quercetin, hydroquinone, or α-peroxyachifolid. Because final product formulations may contain multiple botanicals, each containing similar constituents of concern, formulators are advised to be aware of these components and to avoid reaching levels that may be hazardous to consumers. Additionally, industry was advised to use good manufacturing practices to limit impurities. The Panel concluded that achillea millefolium extract, achillea millefolium flower extract, and achillea millefolium flower/leaf/stem extract are safe in the present practices of use and concentration in cosmetics when formulated to be nonsensitizing.

AB - Cosmetic ingredients derived from Achillea millefolium function in cosmetics as skin-conditioning agents - miscellaneous, skin-conditioning agents - humectants, and fragrance ingredients. The Cosmetic Ingredient Review Expert Panel (Panel) reviewed relevant animal and human data to determine their safety in cosmetics and raised concerns about cosmetics containing linalool, thujone, quercetin, hydroquinone, or α-peroxyachifolid. Because final product formulations may contain multiple botanicals, each containing similar constituents of concern, formulators are advised to be aware of these components and to avoid reaching levels that may be hazardous to consumers. Additionally, industry was advised to use good manufacturing practices to limit impurities. The Panel concluded that achillea millefolium extract, achillea millefolium flower extract, and achillea millefolium flower/leaf/stem extract are safe in the present practices of use and concentration in cosmetics when formulated to be nonsensitizing.

UR - http://www.scopus.com/inward/record.url?scp=85001070129&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85001070129&partnerID=8YFLogxK

U2 - 10.1177/1091581816677717

DO - 10.1177/1091581816677717

M3 - Article

VL - 35

SP - 5S-15S

JO - International Journal of Toxicology

JF - International Journal of Toxicology

SN - 1091-5818

IS - 3_suppl

ER -

Becker LC, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC et al. Safety Assessment of Achillea millefolium as Used in Cosmetics. International Journal of Toxicology. 2016 Nov 1;35(3_suppl):5S-15S. https://doi.org/10.1177/1091581816677717