Safety Assessment of Alkyl Benzoates as Used in Cosmetics

Lillian C. ’becker, Wilma F. Bergfeld, Donald V. Belsito, Ronald A. Hill, Curtis D. Klaassen, Daniel Liebler, James Marks, Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder, F. Alan Andersen

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The functions of alkyl benzoates in cosmetics include fragrance ingredients, skin-conditioning agents—emollient, skin-conditioning agents—miscellaneous, preservatives, solvents, and plasticizers. The Cosmetic Ingredient Review Expert Panel reviewed the relevant animal and human data and noted gaps in the available safety data for some of the alkyl benzoates. Similar structure activity relationships, biologic functions, and cosmetic product usage allowed the available data of many of the alkyl benzoates to be extended to the entire group. Carcinogenicity data were not available, but available data indicated that these alkyl benzoate cosmetic ingredients are not genotoxic. Also benzoic acid and tested component alcohols were not reproductive or developmental toxicants, are not genotoxic in almost all assays, and are not carcinogenic. These ingredients were determined to be safe in the present practices of use and concentration.

Original languageEnglish (US)
Pages (from-to)342S-372S
JournalInternational journal of toxicology
Volume31
DOIs
StatePublished - Jan 1 2012

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Cosmetics
Benzoates
Safety
Skin
Fragrances
Plasticizers
Benzoic Acid
Structure-Activity Relationship
Assays
Animals
Alcohols

All Science Journal Classification (ASJC) codes

  • Toxicology

Cite this

’becker, L. C., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., Liebler, D., ... Andersen, F. A. (2012). Safety Assessment of Alkyl Benzoates as Used in Cosmetics. International journal of toxicology, 31, 342S-372S. https://doi.org/10.1177/1091581812467379
’becker, Lillian C. ; Bergfeld, Wilma F. ; Belsito, Donald V. ; Hill, Ronald A. ; Klaassen, Curtis D. ; Liebler, Daniel ; Marks, James ; Shank, Ronald C. ; Slaga, Thomas J. ; Snyder, Paul W. ; Andersen, F. Alan. / Safety Assessment of Alkyl Benzoates as Used in Cosmetics. In: International journal of toxicology. 2012 ; Vol. 31. pp. 342S-372S.
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’becker, LC, Bergfeld, WF, Belsito, DV, Hill, RA, Klaassen, CD, Liebler, D, Marks, J, Shank, RC, Slaga, TJ, Snyder, PW & Andersen, FA 2012, 'Safety Assessment of Alkyl Benzoates as Used in Cosmetics', International journal of toxicology, vol. 31, pp. 342S-372S. https://doi.org/10.1177/1091581812467379

Safety Assessment of Alkyl Benzoates as Used in Cosmetics. / ’becker, Lillian C.; Bergfeld, Wilma F.; Belsito, Donald V.; Hill, Ronald A.; Klaassen, Curtis D.; Liebler, Daniel; Marks, James; Shank, Ronald C.; Slaga, Thomas J.; Snyder, Paul W.; Andersen, F. Alan.

In: International journal of toxicology, Vol. 31, 01.01.2012, p. 342S-372S.

Research output: Contribution to journalArticle

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’becker LC, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler D et al. Safety Assessment of Alkyl Benzoates as Used in Cosmetics. International journal of toxicology. 2012 Jan 1;31:342S-372S. https://doi.org/10.1177/1091581812467379