Safety Assessment of Alkyl Betaines as Used in Cosmetics

Christina L. Burnett, Wilma F. Bergfeld, Donald V. Belsito, Ronald A. Hill, Curtis D. Klaassen, Daniel C. Liebler, James Marks, Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder, F. Alan Andersen, Bart Heldreth

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The Cosmetic Ingredient Review Expert Panel (Panel) reviewed the safety of 11 alkyl betaines as used in cosmetics. These ingredients are reported to function as hair and skin conditioning agents, antistatic agents, surfactants-cleansing agents, and viscosity-increasing agents in cosmetic products. Although there are data gaps, the shared chemical core structure, similar functions and concentrations of use in cosmetics, and the expected similarities in physicochemical properties enabled grouping these ingredients and reading across the available toxicological data to support the safety assessment of each individual compound in the entire group. The Panel concluded alkyl betaines were safe as cosmetic ingredients in the present practices of use and concentration, when formulated to be nonirritating.

Original languageEnglish (US)
Pages (from-to)28S-46S
JournalInternational journal of toxicology
Volume37
Issue number1_suppl
DOIs
StatePublished - May 1 2018

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Betaine
Cosmetics
Safety
Antistatic Agents
Surface-Active Agents
Viscosity
Detergents
Hair
Toxicology
Reading
Skin

All Science Journal Classification (ASJC) codes

  • Toxicology

Cite this

Burnett, C. L., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., Liebler, D. C., ... Heldreth, B. (2018). Safety Assessment of Alkyl Betaines as Used in Cosmetics. International journal of toxicology, 37(1_suppl), 28S-46S. https://doi.org/10.1177/1091581818773354
Burnett, Christina L. ; Bergfeld, Wilma F. ; Belsito, Donald V. ; Hill, Ronald A. ; Klaassen, Curtis D. ; Liebler, Daniel C. ; Marks, James ; Shank, Ronald C. ; Slaga, Thomas J. ; Snyder, Paul W. ; Andersen, F. Alan ; Heldreth, Bart. / Safety Assessment of Alkyl Betaines as Used in Cosmetics. In: International journal of toxicology. 2018 ; Vol. 37, No. 1_suppl. pp. 28S-46S.
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Burnett, CL, Bergfeld, WF, Belsito, DV, Hill, RA, Klaassen, CD, Liebler, DC, Marks, J, Shank, RC, Slaga, TJ, Snyder, PW, Andersen, FA & Heldreth, B 2018, 'Safety Assessment of Alkyl Betaines as Used in Cosmetics', International journal of toxicology, vol. 37, no. 1_suppl, pp. 28S-46S. https://doi.org/10.1177/1091581818773354

Safety Assessment of Alkyl Betaines as Used in Cosmetics. / Burnett, Christina L.; Bergfeld, Wilma F.; Belsito, Donald V.; Hill, Ronald A.; Klaassen, Curtis D.; Liebler, Daniel C.; Marks, James; Shank, Ronald C.; Slaga, Thomas J.; Snyder, Paul W.; Andersen, F. Alan; Heldreth, Bart.

In: International journal of toxicology, Vol. 37, No. 1_suppl, 01.05.2018, p. 28S-46S.

Research output: Contribution to journalArticle

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Burnett CL, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC et al. Safety Assessment of Alkyl Betaines as Used in Cosmetics. International journal of toxicology. 2018 May 1;37(1_suppl):28S-46S. https://doi.org/10.1177/1091581818773354