Safety Assessment of Alkyl Ethylhexanoates as Used in Cosmetics

Monice Fiume, B. A.R.T. Heldreth, Wilma F. Bergfeld, Donald V. Belsito, Ronald A. Hill, Curtis D. Klaassen, Daniel C. Liebler, James G. Marks, Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder, F. Alan Andersen, Lillian J. Gill

Research output: Contribution to journalReview article

2 Scopus citations

Abstract

The Cosmetic Ingredient Review (CIR) Expert Panel (Panel) assessed the safety of 16 alkyl ethylhexanoates for use in cosmetics, concluding that these ingredients are safe in cosmetic formulations in the present practices of use and concentrations when formulated to be nonirritating. The alkyl ethylhexanoates primarily function as skin-conditioning agents in cosmetics. The highest concentration of use reported for any of the alkyl ethylhexanoates is 77.3% cetyl ethylhexanoate in rinse-off formulations used near the eye, and the highest leave-on use reported is 52% cetyl ethylhexanoate in lipstick formulations. The Panel reviewed available animal and clinical data related to these ingredients, and the similarities in structure, properties, functions, and uses of ingredients from previous CIR assessments on constituent alcohols that allowed for extrapolation of the available toxicological data to assess the safety of the entire group.

Original languageEnglish (US)
Pages (from-to)61S-73S
JournalInternational journal of toxicology
Volume34
DOIs
StatePublished - Nov 1 2015

All Science Journal Classification (ASJC) codes

  • Toxicology

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    Fiume, M., Heldreth, B. A. R. T., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., Liebler, D. C., Marks, J. G., Shank, R. C., Slaga, T. J., Snyder, P. W., Andersen, F. A., & Gill, L. J. (2015). Safety Assessment of Alkyl Ethylhexanoates as Used in Cosmetics. International journal of toxicology, 34, 61S-73S. https://doi.org/10.1177/1091581815617794