Safety Assessment of Alkyl Phosphates as Used in Cosmetics

Monice M. Fiume, Wilma F. Bergfeld, Donald V. Belsito, Ronald A. Hill, Curtis D. Klaassen, Daniel C. Liebler, James Marks, Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder, Lillian J. Gill, Bart Heldreth

Research output: Contribution to journalArticle

Abstract

The Expert Panel assessed the safety of 28 alkyl phosphates and concluded that these ingredients are safe in the current practices of use and concentration when formulated to be nonirritating. The ingredients in the alkyl phosphate family share a common phosphate core structure, and vary by the identity of the alkyl chains attached therein. Most of the alkyl phosphates function as surfactants in cosmetic ingredients; however, the triesters function as plasticizers rather than surfactants. The Panel reviewed the available animal and clinical data to determine the safety of these ingredients.

Original languageEnglish (US)
Pages (from-to)12S-32S
JournalInternational journal of toxicology
Volume38
Issue number2_suppl
DOIs
StatePublished - Sep 1 2019

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Cosmetics
Phosphates
Safety
Surface-Active Agents
Plasticizers
Animals

All Science Journal Classification (ASJC) codes

  • Toxicology

Cite this

Fiume, M. M., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., Liebler, D. C., ... Heldreth, B. (2019). Safety Assessment of Alkyl Phosphates as Used in Cosmetics. International journal of toxicology, 38(2_suppl), 12S-32S. https://doi.org/10.1177/1091581819856582
Fiume, Monice M. ; Bergfeld, Wilma F. ; Belsito, Donald V. ; Hill, Ronald A. ; Klaassen, Curtis D. ; Liebler, Daniel C. ; Marks, James ; Shank, Ronald C. ; Slaga, Thomas J. ; Snyder, Paul W. ; Gill, Lillian J. ; Heldreth, Bart. / Safety Assessment of Alkyl Phosphates as Used in Cosmetics. In: International journal of toxicology. 2019 ; Vol. 38, No. 2_suppl. pp. 12S-32S.
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Fiume, MM, Bergfeld, WF, Belsito, DV, Hill, RA, Klaassen, CD, Liebler, DC, Marks, J, Shank, RC, Slaga, TJ, Snyder, PW, Gill, LJ & Heldreth, B 2019, 'Safety Assessment of Alkyl Phosphates as Used in Cosmetics', International journal of toxicology, vol. 38, no. 2_suppl, pp. 12S-32S. https://doi.org/10.1177/1091581819856582

Safety Assessment of Alkyl Phosphates as Used in Cosmetics. / Fiume, Monice M.; Bergfeld, Wilma F.; Belsito, Donald V.; Hill, Ronald A.; Klaassen, Curtis D.; Liebler, Daniel C.; Marks, James; Shank, Ronald C.; Slaga, Thomas J.; Snyder, Paul W.; Gill, Lillian J.; Heldreth, Bart.

In: International journal of toxicology, Vol. 38, No. 2_suppl, 01.09.2019, p. 12S-32S.

Research output: Contribution to journalArticle

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Fiume MM, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC et al. Safety Assessment of Alkyl Phosphates as Used in Cosmetics. International journal of toxicology. 2019 Sep 1;38(2_suppl):12S-32S. https://doi.org/10.1177/1091581819856582