Safety Assessment of Diethanolamides as Used in Cosmetics

Monice M. Fiume, Bart Heldreth, Wilma F. Bergfeld, Donald V. Belsito, Ronald A. Hill, Curtis D. Klaassen, Daniel C. Liebler, James G. Marks, Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder, F. Alan Andersen

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Cocamide diethanolamine (DEA) and some of the other diethanolamides are mainly used as surfactant foam boosters or viscosity increasing agents in cosmetics, although a few are reported to be used as hair and skin conditioning agents, surfactant-cleansing or surfactant-emulsifying agents, or as an opacifying agent. The Cosmetic Ingredient Review (CIR) Expert Panel considered new data and information from previous CIR reports to assess the concerns about the potential for amidases in human skin to convert these diethanolamides into DEA and the corresponding fatty acids. The Expert Panel concluded that these diethanolamides are safe as used when formulated to be nonirritating and when the levels of free DEA in the diethanolamides do not exceed those considered safe by the Panel. The Panel also recommended that these ingredients not be used in cosmetic products in which N-nitroso compounds can be formed.

Original languageEnglish (US)
Pages (from-to)36S-58S
JournalInternational journal of toxicology
Volume32
DOIs
StatePublished - May 2013

Fingerprint

diethanolamine
Cosmetics
Surface-Active Agents
Safety
Skin
Emulsifying Agents
Amidohydrolases
Nitroso Compounds
Viscosity
Detergents
Hair
Foams
Fatty Acids

All Science Journal Classification (ASJC) codes

  • Toxicology

Cite this

Fiume, M. M., Heldreth, B., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., ... Andersen, F. A. (2013). Safety Assessment of Diethanolamides as Used in Cosmetics. International journal of toxicology, 32, 36S-58S. https://doi.org/10.1177/1091581813486300
Fiume, Monice M. ; Heldreth, Bart ; Bergfeld, Wilma F. ; Belsito, Donald V. ; Hill, Ronald A. ; Klaassen, Curtis D. ; Liebler, Daniel C. ; Marks, James G. ; Shank, Ronald C. ; Slaga, Thomas J. ; Snyder, Paul W. ; Andersen, F. Alan. / Safety Assessment of Diethanolamides as Used in Cosmetics. In: International journal of toxicology. 2013 ; Vol. 32. pp. 36S-58S.
@article{4828bbedd7194500b89b1d25306ffe61,
title = "Safety Assessment of Diethanolamides as Used in Cosmetics",
abstract = "Cocamide diethanolamine (DEA) and some of the other diethanolamides are mainly used as surfactant foam boosters or viscosity increasing agents in cosmetics, although a few are reported to be used as hair and skin conditioning agents, surfactant-cleansing or surfactant-emulsifying agents, or as an opacifying agent. The Cosmetic Ingredient Review (CIR) Expert Panel considered new data and information from previous CIR reports to assess the concerns about the potential for amidases in human skin to convert these diethanolamides into DEA and the corresponding fatty acids. The Expert Panel concluded that these diethanolamides are safe as used when formulated to be nonirritating and when the levels of free DEA in the diethanolamides do not exceed those considered safe by the Panel. The Panel also recommended that these ingredients not be used in cosmetic products in which N-nitroso compounds can be formed.",
author = "Fiume, {Monice M.} and Bart Heldreth and Bergfeld, {Wilma F.} and Belsito, {Donald V.} and Hill, {Ronald A.} and Klaassen, {Curtis D.} and Liebler, {Daniel C.} and Marks, {James G.} and Shank, {Ronald C.} and Slaga, {Thomas J.} and Snyder, {Paul W.} and Andersen, {F. Alan}",
year = "2013",
month = "5",
doi = "10.1177/1091581813486300",
language = "English (US)",
volume = "32",
pages = "36S--58S",
journal = "International Journal of Toxicology",
issn = "1091-5818",
publisher = "SAGE Publications Inc.",

}

Fiume, MM, Heldreth, B, Bergfeld, WF, Belsito, DV, Hill, RA, Klaassen, CD, Liebler, DC, Marks, JG, Shank, RC, Slaga, TJ, Snyder, PW & Andersen, FA 2013, 'Safety Assessment of Diethanolamides as Used in Cosmetics', International journal of toxicology, vol. 32, pp. 36S-58S. https://doi.org/10.1177/1091581813486300

Safety Assessment of Diethanolamides as Used in Cosmetics. / Fiume, Monice M.; Heldreth, Bart; Bergfeld, Wilma F.; Belsito, Donald V.; Hill, Ronald A.; Klaassen, Curtis D.; Liebler, Daniel C.; Marks, James G.; Shank, Ronald C.; Slaga, Thomas J.; Snyder, Paul W.; Andersen, F. Alan.

In: International journal of toxicology, Vol. 32, 05.2013, p. 36S-58S.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Safety Assessment of Diethanolamides as Used in Cosmetics

AU - Fiume, Monice M.

AU - Heldreth, Bart

AU - Bergfeld, Wilma F.

AU - Belsito, Donald V.

AU - Hill, Ronald A.

AU - Klaassen, Curtis D.

AU - Liebler, Daniel C.

AU - Marks, James G.

AU - Shank, Ronald C.

AU - Slaga, Thomas J.

AU - Snyder, Paul W.

AU - Andersen, F. Alan

PY - 2013/5

Y1 - 2013/5

N2 - Cocamide diethanolamine (DEA) and some of the other diethanolamides are mainly used as surfactant foam boosters or viscosity increasing agents in cosmetics, although a few are reported to be used as hair and skin conditioning agents, surfactant-cleansing or surfactant-emulsifying agents, or as an opacifying agent. The Cosmetic Ingredient Review (CIR) Expert Panel considered new data and information from previous CIR reports to assess the concerns about the potential for amidases in human skin to convert these diethanolamides into DEA and the corresponding fatty acids. The Expert Panel concluded that these diethanolamides are safe as used when formulated to be nonirritating and when the levels of free DEA in the diethanolamides do not exceed those considered safe by the Panel. The Panel also recommended that these ingredients not be used in cosmetic products in which N-nitroso compounds can be formed.

AB - Cocamide diethanolamine (DEA) and some of the other diethanolamides are mainly used as surfactant foam boosters or viscosity increasing agents in cosmetics, although a few are reported to be used as hair and skin conditioning agents, surfactant-cleansing or surfactant-emulsifying agents, or as an opacifying agent. The Cosmetic Ingredient Review (CIR) Expert Panel considered new data and information from previous CIR reports to assess the concerns about the potential for amidases in human skin to convert these diethanolamides into DEA and the corresponding fatty acids. The Expert Panel concluded that these diethanolamides are safe as used when formulated to be nonirritating and when the levels of free DEA in the diethanolamides do not exceed those considered safe by the Panel. The Panel also recommended that these ingredients not be used in cosmetic products in which N-nitroso compounds can be formed.

UR - http://www.scopus.com/inward/record.url?scp=84890065541&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84890065541&partnerID=8YFLogxK

U2 - 10.1177/1091581813486300

DO - 10.1177/1091581813486300

M3 - Article

C2 - 23696577

AN - SCOPUS:84890065541

VL - 32

SP - 36S-58S

JO - International Journal of Toxicology

JF - International Journal of Toxicology

SN - 1091-5818

ER -

Fiume MM, Heldreth B, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD et al. Safety Assessment of Diethanolamides as Used in Cosmetics. International journal of toxicology. 2013 May;32:36S-58S. https://doi.org/10.1177/1091581813486300