Safety Assessment of Dimethiconol and Its Esters and Reaction Products as Used in Cosmetics

Wilbur Johnson, Bart Heldreth, Wilma F. Bergfeld, Donald V. Belsito, Ronald A. Hill, Curtis D. Klaassen, Daniel C. Liebler, James Marks, Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder, F. Alan Andersen

Research output: Contribution to journalArticle

Abstract

Dimethiconol and its esters and reaction products are used in cosmetics as either skin-conditioning agents or hair-conditioning agents. The Cosmetic Ingredient Review (CIR) Expert Panel reviewed relevant data and concluded that these ingredients are safe in the present practices of use and concentration described in this safety assessment. While there is an absence of data on reproductive and developmental toxicity and limited tumorigenicity and toxicokinetics data, the Panel reasoned that these ingredients would not be absorbed through the skin, obviating concern over potential reproductive and developmental toxicity or carcinogenicity.

Original languageEnglish (US)
Pages (from-to)31S-50S
JournalInternational journal of toxicology
Volume36
Issue number3_suppl
DOIs
StatePublished - Nov 1 2017

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Cosmetics
Reaction products
Toxicity
Skin
Esters
Safety
Hair
Toxicokinetics

All Science Journal Classification (ASJC) codes

  • Toxicology

Cite this

Johnson, W., Heldreth, B., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., ... Andersen, F. A. (2017). Safety Assessment of Dimethiconol and Its Esters and Reaction Products as Used in Cosmetics. International journal of toxicology, 36(3_suppl), 31S-50S. https://doi.org/10.1177/1091581817739429
Johnson, Wilbur ; Heldreth, Bart ; Bergfeld, Wilma F. ; Belsito, Donald V. ; Hill, Ronald A. ; Klaassen, Curtis D. ; Liebler, Daniel C. ; Marks, James ; Shank, Ronald C. ; Slaga, Thomas J. ; Snyder, Paul W. ; Andersen, F. Alan. / Safety Assessment of Dimethiconol and Its Esters and Reaction Products as Used in Cosmetics. In: International journal of toxicology. 2017 ; Vol. 36, No. 3_suppl. pp. 31S-50S.
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Johnson, W, Heldreth, B, Bergfeld, WF, Belsito, DV, Hill, RA, Klaassen, CD, Liebler, DC, Marks, J, Shank, RC, Slaga, TJ, Snyder, PW & Andersen, FA 2017, 'Safety Assessment of Dimethiconol and Its Esters and Reaction Products as Used in Cosmetics', International journal of toxicology, vol. 36, no. 3_suppl, pp. 31S-50S. https://doi.org/10.1177/1091581817739429

Safety Assessment of Dimethiconol and Its Esters and Reaction Products as Used in Cosmetics. / Johnson, Wilbur; Heldreth, Bart; Bergfeld, Wilma F.; Belsito, Donald V.; Hill, Ronald A.; Klaassen, Curtis D.; Liebler, Daniel C.; Marks, James; Shank, Ronald C.; Slaga, Thomas J.; Snyder, Paul W.; Andersen, F. Alan.

In: International journal of toxicology, Vol. 36, No. 3_suppl, 01.11.2017, p. 31S-50S.

Research output: Contribution to journalArticle

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Johnson W, Heldreth B, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD et al. Safety Assessment of Dimethiconol and Its Esters and Reaction Products as Used in Cosmetics. International journal of toxicology. 2017 Nov 1;36(3_suppl):31S-50S. https://doi.org/10.1177/1091581817739429