Safety Assessment of Fatty Acid Amidopropyl Dimethylamines as Used in Cosmetics

Christina L. Burnett, Ivan Boyer, Wilma F. Bergfeld, Donald V. Belsito, Ronald A. Hill, Curtis D. Klaassen, Daniel C. Liebler, James Marks, Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder, Lillian J. Gill, Bart Heldreth

Research output: Contribution to journalArticle

Abstract

The Cosmetic Ingredient Review Expert Panel (Panel) reviewed the safety of fatty acid amidopropyl dimethylamines, which function primarily as antistatic agents in cosmetic products. The relevant animal and human data reviewed for these ingredients indicate that they are potential dermal sensitizers that may be due in part by the sensitizing impurity, 3,3-dimethylaminopropylamine. The Panel concluded that fatty acid amidopropyl dimethylamines were safe as cosmetic ingredients when they are formulated to be nonsensitizing, which may be based on a quantitative risk assessment.

Original languageEnglish (US)
Pages (from-to)39S-69S
JournalInternational journal of toxicology
Volume38
Issue number1_suppl
DOIs
StatePublished - May 1 2019

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Dimethylamines
Cosmetics
Fatty Acids
Safety
Antistatic Agents
Risk assessment
Animals
Impurities
Skin

All Science Journal Classification (ASJC) codes

  • Toxicology

Cite this

Burnett, C. L., Boyer, I., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., ... Heldreth, B. (2019). Safety Assessment of Fatty Acid Amidopropyl Dimethylamines as Used in Cosmetics. International journal of toxicology, 38(1_suppl), 39S-69S. https://doi.org/10.1177/1091581819836089
Burnett, Christina L. ; Boyer, Ivan ; Bergfeld, Wilma F. ; Belsito, Donald V. ; Hill, Ronald A. ; Klaassen, Curtis D. ; Liebler, Daniel C. ; Marks, James ; Shank, Ronald C. ; Slaga, Thomas J. ; Snyder, Paul W. ; Gill, Lillian J. ; Heldreth, Bart. / Safety Assessment of Fatty Acid Amidopropyl Dimethylamines as Used in Cosmetics. In: International journal of toxicology. 2019 ; Vol. 38, No. 1_suppl. pp. 39S-69S.
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Burnett, CL, Boyer, I, Bergfeld, WF, Belsito, DV, Hill, RA, Klaassen, CD, Liebler, DC, Marks, J, Shank, RC, Slaga, TJ, Snyder, PW, Gill, LJ & Heldreth, B 2019, 'Safety Assessment of Fatty Acid Amidopropyl Dimethylamines as Used in Cosmetics', International journal of toxicology, vol. 38, no. 1_suppl, pp. 39S-69S. https://doi.org/10.1177/1091581819836089

Safety Assessment of Fatty Acid Amidopropyl Dimethylamines as Used in Cosmetics. / Burnett, Christina L.; Boyer, Ivan; Bergfeld, Wilma F.; Belsito, Donald V.; Hill, Ronald A.; Klaassen, Curtis D.; Liebler, Daniel C.; Marks, James; Shank, Ronald C.; Slaga, Thomas J.; Snyder, Paul W.; Gill, Lillian J.; Heldreth, Bart.

In: International journal of toxicology, Vol. 38, No. 1_suppl, 01.05.2019, p. 39S-69S.

Research output: Contribution to journalArticle

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Burnett CL, Boyer I, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD et al. Safety Assessment of Fatty Acid Amidopropyl Dimethylamines as Used in Cosmetics. International journal of toxicology. 2019 May 1;38(1_suppl):39S-69S. https://doi.org/10.1177/1091581819836089