Safety Assessment of Hydroxypropyl Bis(N -Hydroxyethyl- p -Phenylenediamine) HCl as Used in Cosmetics

Lillian C. Becker, Wilma F. Bergfeld, Donald V. Belsito, Ronald A. Hill, Curtis D. Klaassen, Daniel C. Liebler, James G. Marks, Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder, F. Alan Andersen, Lillian J. Gill

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Abstract

The Cosmetic Ingredient Review Expert Panel (CIR Panel) reviewed the safety of hydroxypropyl bis(N-Hydroxyethyl-p-Phenylenediamine) HCl, which functions as an oxidative hair dye ingredient. The Panel considered relevant animal and human data provided in this safety assessment and concluded that hydroxypropyl bis(N-hydroxyethyl-p-phenylenediamine) HCl is safe for use in oxidative hair dye formulations as described in this safety assessment.

Original languageEnglish (US)
Pages (from-to)5S-11S
JournalInternational journal of toxicology
Volume35
Issue number2_suppl
DOIs
StatePublished - Nov 1 2016

All Science Journal Classification (ASJC) codes

  • Toxicology

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    Becker, L. C., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., Liebler, D. C., Marks, J. G., Shank, R. C., Slaga, T. J., Snyder, P. W., Andersen, F. A., & Gill, L. J. (2016). Safety Assessment of Hydroxypropyl Bis(N -Hydroxyethyl- p -Phenylenediamine) HCl as Used in Cosmetics. International journal of toxicology, 35(2_suppl), 5S-11S. https://doi.org/10.1177/1091581816659258