Safety Assessment of Magnesium Sulfate as Used in Cosmetics

Wilbur Johnson, Wilma F. Bergfeld, Donald V. Belsito, Ronald A. Hill, Curtis D. Klaassen, Daniel C. Liebler, James Marks, Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder, F. Alan Andersen, Bart Heldreth

Research output: Contribution to journalArticle

Abstract

The Cosmetic Ingredient Review Expert Panel (Panel) reviewed the safety of magnesium sulfate, which functions as a bulking agent in cosmetic products and is reportedly used at concentrations up to 11% and 25% in leave-on and rinse-off products, respectively. The Panel noted that the history of safe medical use of magnesium sulfate provides further confidence that there are no significant toxicity concerns relating to systemic exposure to this ingredient after cosmetic product application. Furthermore, the extensive clinical experience of the Panel, including the results of numerous patch tests, indicates that magnesium salts do not have the potential to induce sensitization. The Panel also noted that results were negative for 50% magnesium sulfate in a mouse skin irritation study and in an in vitro sensitization assay. The Panel concluded that magnesium sulfate is safe in cosmetics in the present practices of use and concentration described in the safety assessment.

Original languageEnglish (US)
Pages (from-to)47S-54S
JournalInternational journal of toxicology
Volume37
Issue number1_suppl
DOIs
StatePublished - May 1 2018

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Magnesium Sulfate
Cosmetics
Safety
Patch Tests
Magnesium
Toxicity
Assays
Skin
Salts
History

All Science Journal Classification (ASJC) codes

  • Toxicology

Cite this

Johnson, W., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., Liebler, D. C., ... Heldreth, B. (2018). Safety Assessment of Magnesium Sulfate as Used in Cosmetics. International journal of toxicology, 37(1_suppl), 47S-54S. https://doi.org/10.1177/1091581818773355
Johnson, Wilbur ; Bergfeld, Wilma F. ; Belsito, Donald V. ; Hill, Ronald A. ; Klaassen, Curtis D. ; Liebler, Daniel C. ; Marks, James ; Shank, Ronald C. ; Slaga, Thomas J. ; Snyder, Paul W. ; Andersen, F. Alan ; Heldreth, Bart. / Safety Assessment of Magnesium Sulfate as Used in Cosmetics. In: International journal of toxicology. 2018 ; Vol. 37, No. 1_suppl. pp. 47S-54S.
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Johnson, W, Bergfeld, WF, Belsito, DV, Hill, RA, Klaassen, CD, Liebler, DC, Marks, J, Shank, RC, Slaga, TJ, Snyder, PW, Andersen, FA & Heldreth, B 2018, 'Safety Assessment of Magnesium Sulfate as Used in Cosmetics', International journal of toxicology, vol. 37, no. 1_suppl, pp. 47S-54S. https://doi.org/10.1177/1091581818773355

Safety Assessment of Magnesium Sulfate as Used in Cosmetics. / Johnson, Wilbur; Bergfeld, Wilma F.; Belsito, Donald V.; Hill, Ronald A.; Klaassen, Curtis D.; Liebler, Daniel C.; Marks, James; Shank, Ronald C.; Slaga, Thomas J.; Snyder, Paul W.; Andersen, F. Alan; Heldreth, Bart.

In: International journal of toxicology, Vol. 37, No. 1_suppl, 01.05.2018, p. 47S-54S.

Research output: Contribution to journalArticle

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Johnson W, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC et al. Safety Assessment of Magnesium Sulfate as Used in Cosmetics. International journal of toxicology. 2018 May 1;37(1_suppl):47S-54S. https://doi.org/10.1177/1091581818773355