Safety Assessment of PEG-150 Pentaerythrityl Tetrastearate as Used in Cosmetics

Wilbur Johnson, Wilma F. Bergfeld, Donald V. Belsito, Ronald A. Hill, Curtis D. Klaassen, Daniel C. Liebler, James Marks, Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder, F. Alan Andersen, Bart Heldreth

Research output: Contribution to journalArticle

Abstract

The Cosmetic Ingredient Review Expert Panel (Panel) reviewed the safety of polyethylene glycol (PEG)-150 pentaerythrityl tetrastearate, which functions as a viscosity-increasing agent-aqueous in cosmetic products and is being used at concentrations up to 5%. Given the chemical structure (large molecule), skin penetration is not likely. The available toxicity data and the low ingredient use concentrations suggest that systemic toxicity would not be likely even if percutaneous absorption were to occur. Additionally, the negative human repeated insult patch test data on the undiluted ingredient were deemed sufficient for evaluating skin irritation and sensitization potential. The Panel concluded that PEG-150 pentaerythrityl tetrastearate is safe in cosmetics in the present practices of use and concentration described in this safety assessment.

Original languageEnglish (US)
Pages (from-to)5S-9S
JournalInternational journal of toxicology
Volume37
Issue number2_suppl
DOIs
StatePublished - Sep 1 2018

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Cosmetics
Safety
Toxicity
Skin
Skin Absorption
Patch Tests
Viscosity
Molecules

All Science Journal Classification (ASJC) codes

  • Toxicology

Cite this

Johnson, W., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., Liebler, D. C., ... Heldreth, B. (2018). Safety Assessment of PEG-150 Pentaerythrityl Tetrastearate as Used in Cosmetics. International journal of toxicology, 37(2_suppl), 5S-9S. https://doi.org/10.1177/1091581818794457
Johnson, Wilbur ; Bergfeld, Wilma F. ; Belsito, Donald V. ; Hill, Ronald A. ; Klaassen, Curtis D. ; Liebler, Daniel C. ; Marks, James ; Shank, Ronald C. ; Slaga, Thomas J. ; Snyder, Paul W. ; Andersen, F. Alan ; Heldreth, Bart. / Safety Assessment of PEG-150 Pentaerythrityl Tetrastearate as Used in Cosmetics. In: International journal of toxicology. 2018 ; Vol. 37, No. 2_suppl. pp. 5S-9S.
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Johnson, W, Bergfeld, WF, Belsito, DV, Hill, RA, Klaassen, CD, Liebler, DC, Marks, J, Shank, RC, Slaga, TJ, Snyder, PW, Andersen, FA & Heldreth, B 2018, 'Safety Assessment of PEG-150 Pentaerythrityl Tetrastearate as Used in Cosmetics', International journal of toxicology, vol. 37, no. 2_suppl, pp. 5S-9S. https://doi.org/10.1177/1091581818794457

Safety Assessment of PEG-150 Pentaerythrityl Tetrastearate as Used in Cosmetics. / Johnson, Wilbur; Bergfeld, Wilma F.; Belsito, Donald V.; Hill, Ronald A.; Klaassen, Curtis D.; Liebler, Daniel C.; Marks, James; Shank, Ronald C.; Slaga, Thomas J.; Snyder, Paul W.; Andersen, F. Alan; Heldreth, Bart.

In: International journal of toxicology, Vol. 37, No. 2_suppl, 01.09.2018, p. 5S-9S.

Research output: Contribution to journalArticle

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Johnson W, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC et al. Safety Assessment of PEG-150 Pentaerythrityl Tetrastearate as Used in Cosmetics. International journal of toxicology. 2018 Sep 1;37(2_suppl):5S-9S. https://doi.org/10.1177/1091581818794457