Safety Assessment of Silylates and Surface-Modified Siloxysilicates

Monice M. Fiume, Bart Heldreth, Wilma F. Bergfeld, Donald V. Belsito, Ronald A. Hill, Curtis D. Klaassen, Daniel Liebler, James G. Marks, Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder, F. Alan Andersen

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The Cosmetic Ingredient Review (CIR) Expert Panel assessed the safety of silica silylate, silica dimethyl silylate, trimethylsiloxysilicate, and trifluoropropyldimethyl/trimethylsiloxysilicate as used in cosmetics. These silylates and surface-modified siloxysilicates function in cosmetics as antifoaming agents, anticaking agents, bulking agents, binders, skin-conditioning agents—emollient, skin-conditioning agents—occlusive, slip modifiers, suspension agents—nonsurfactant, and viscosity increasing agents—nonaqueous. The Expert Panel reviewed the available animal and clinical data as well as information from a previous CIR safety assessment of amorphous silica. The CIR Expert Panel concluded that silica silylate, silica dimethyl silylate, trimethylsiloxysilicate, and trifluoropropyldimethyl/trimethylsiloxysilicate are safe as used when formulated and delivered in the final product not to be irritating or sensitizing to the respiratory tract.

Original languageEnglish (US)
Pages (from-to)5S-24S
JournalInternational journal of toxicology
Volume32
DOIs
StatePublished - May 2013

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Cosmetics
Silicon Dioxide
Safety
Antifoaming Agents
Skin
Viscosity
Respiratory System
Binders
Suspensions
Animals

All Science Journal Classification (ASJC) codes

  • Toxicology

Cite this

Fiume, M. M., Heldreth, B., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., ... Andersen, F. A. (2013). Safety Assessment of Silylates and Surface-Modified Siloxysilicates. International journal of toxicology, 32, 5S-24S. https://doi.org/10.1177/1091581813486299
Fiume, Monice M. ; Heldreth, Bart ; Bergfeld, Wilma F. ; Belsito, Donald V. ; Hill, Ronald A. ; Klaassen, Curtis D. ; Liebler, Daniel ; Marks, James G. ; Shank, Ronald C. ; Slaga, Thomas J. ; Snyder, Paul W. ; Andersen, F. Alan. / Safety Assessment of Silylates and Surface-Modified Siloxysilicates. In: International journal of toxicology. 2013 ; Vol. 32. pp. 5S-24S.
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Fiume, MM, Heldreth, B, Bergfeld, WF, Belsito, DV, Hill, RA, Klaassen, CD, Liebler, D, Marks, JG, Shank, RC, Slaga, TJ, Snyder, PW & Andersen, FA 2013, 'Safety Assessment of Silylates and Surface-Modified Siloxysilicates', International journal of toxicology, vol. 32, pp. 5S-24S. https://doi.org/10.1177/1091581813486299

Safety Assessment of Silylates and Surface-Modified Siloxysilicates. / Fiume, Monice M.; Heldreth, Bart; Bergfeld, Wilma F.; Belsito, Donald V.; Hill, Ronald A.; Klaassen, Curtis D.; Liebler, Daniel; Marks, James G.; Shank, Ronald C.; Slaga, Thomas J.; Snyder, Paul W.; Andersen, F. Alan.

In: International journal of toxicology, Vol. 32, 05.2013, p. 5S-24S.

Research output: Contribution to journalArticle

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Fiume MM, Heldreth B, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD et al. Safety Assessment of Silylates and Surface-Modified Siloxysilicates. International journal of toxicology. 2013 May;32:5S-24S. https://doi.org/10.1177/1091581813486299