Safety Assessment of Tocopherols and Tocotrienols as Used in Cosmetics

Monice M. Fiume, Wilma F. Bergfeld, Donald V. Belsito, Ronald A. Hill, Curtis D. Klaassen, Daniel C. Liebler, James Marks, Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder, F. Alan Andersen, Bart Heldreth

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The Cosmetic Ingredient Review (CIR) Expert Panel (Panel) assessed the safety of 14 tocopherols and tocotrienols and concluded these ingredients are safe as used in cosmetics. The tocopherols are reported to function in cosmetics as antioxidants or skin-conditioning agents; in contrast, tocotrienols are not reported to function as an antioxidants in cosmetics but as a light stabilizer, oral care agent, or skin-conditioning agent. The Panel reviewed the new and existing animal and clinical data to determine the safety of these ingredients and found it appropriate to extrapolate the existing information to conclude on the safety of all the tocopherols and tocotrienols.

Original languageEnglish (US)
Pages (from-to)61S-94S
JournalInternational journal of toxicology
Volume37
Issue number2_suppl
DOIs
StatePublished - Sep 1 2018

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Tocotrienols
Tocopherols
Cosmetics
Safety
Skin
Antioxidants
Stabilizers (agents)
Animals
Light

All Science Journal Classification (ASJC) codes

  • Toxicology

Cite this

Fiume, M. M., Bergfeld, W. F., Belsito, D. V., Hill, R. A., Klaassen, C. D., Liebler, D. C., ... Heldreth, B. (2018). Safety Assessment of Tocopherols and Tocotrienols as Used in Cosmetics. International journal of toxicology, 37(2_suppl), 61S-94S. https://doi.org/10.1177/1091581818794455
Fiume, Monice M. ; Bergfeld, Wilma F. ; Belsito, Donald V. ; Hill, Ronald A. ; Klaassen, Curtis D. ; Liebler, Daniel C. ; Marks, James ; Shank, Ronald C. ; Slaga, Thomas J. ; Snyder, Paul W. ; Andersen, F. Alan ; Heldreth, Bart. / Safety Assessment of Tocopherols and Tocotrienols as Used in Cosmetics. In: International journal of toxicology. 2018 ; Vol. 37, No. 2_suppl. pp. 61S-94S.
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Fiume, MM, Bergfeld, WF, Belsito, DV, Hill, RA, Klaassen, CD, Liebler, DC, Marks, J, Shank, RC, Slaga, TJ, Snyder, PW, Andersen, FA & Heldreth, B 2018, 'Safety Assessment of Tocopherols and Tocotrienols as Used in Cosmetics', International journal of toxicology, vol. 37, no. 2_suppl, pp. 61S-94S. https://doi.org/10.1177/1091581818794455

Safety Assessment of Tocopherols and Tocotrienols as Used in Cosmetics. / Fiume, Monice M.; Bergfeld, Wilma F.; Belsito, Donald V.; Hill, Ronald A.; Klaassen, Curtis D.; Liebler, Daniel C.; Marks, James; Shank, Ronald C.; Slaga, Thomas J.; Snyder, Paul W.; Andersen, F. Alan; Heldreth, Bart.

In: International journal of toxicology, Vol. 37, No. 2_suppl, 01.09.2018, p. 61S-94S.

Research output: Contribution to journalArticle

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Fiume MM, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC et al. Safety Assessment of Tocopherols and Tocotrienols as Used in Cosmetics. International journal of toxicology. 2018 Sep 1;37(2_suppl):61S-94S. https://doi.org/10.1177/1091581818794455