Safety Assessment of Tocopherols and Tocotrienols as Used in Cosmetics

Monice M. Fiume; Wilma F. Bergfeld; Donald V. Belsito; Ronald A. Hill; Curtis D. Klaassen; Daniel C. Liebler; James G. Marks; Ronald C. Shank; Thomas J. Slaga; Paul W. Snyder; F. Alan Andersen; Bart Heldreth

doi:10.1177/1091581818794455

Safety Assessment of Tocopherols and Tocotrienols as Used in Cosmetics

Monice M. Fiume, Wilma F. Bergfeld, Donald V. Belsito, Ronald A. Hill, Curtis D. Klaassen, Daniel C. Liebler, James G. Marks, Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder, F. Alan Andersen, Bart Heldreth

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

The Cosmetic Ingredient Review (CIR) Expert Panel (Panel) assessed the safety of 14 tocopherols and tocotrienols and concluded these ingredients are safe as used in cosmetics. The tocopherols are reported to function in cosmetics as antioxidants or skin-conditioning agents; in contrast, tocotrienols are not reported to function as an antioxidants in cosmetics but as a light stabilizer, oral care agent, or skin-conditioning agent. The Panel reviewed the new and existing animal and clinical data to determine the safety of these ingredients and found it appropriate to extrapolate the existing information to conclude on the safety of all the tocopherols and tocotrienols.

Original language	English (US)
Pages (from-to)	61S-94S
Journal	International journal of toxicology
Volume	37
Issue number	2_suppl
DOIs	https://doi.org/10.1177/1091581818794455
State	Published - Sep 1 2018

All Science Journal Classification (ASJC) codes

Toxicology

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10.1177/1091581818794455

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Fiume, Monice M. ; Bergfeld, Wilma F. ; Belsito, Donald V. ; Hill, Ronald A. ; Klaassen, Curtis D. ; Liebler, Daniel C. ; Marks, James G. ; Shank, Ronald C. ; Slaga, Thomas J. ; Snyder, Paul W. ; Andersen, F. Alan ; Heldreth, Bart. / Safety Assessment of Tocopherols and Tocotrienols as Used in Cosmetics. In: International journal of toxicology. 2018 ; Vol. 37, No. 2_suppl. pp. 61S-94S.

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title = "Safety Assessment of Tocopherols and Tocotrienols as Used in Cosmetics",

abstract = "The Cosmetic Ingredient Review (CIR) Expert Panel (Panel) assessed the safety of 14 tocopherols and tocotrienols and concluded these ingredients are safe as used in cosmetics. The tocopherols are reported to function in cosmetics as antioxidants or skin-conditioning agents; in contrast, tocotrienols are not reported to function as an antioxidants in cosmetics but as a light stabilizer, oral care agent, or skin-conditioning agent. The Panel reviewed the new and existing animal and clinical data to determine the safety of these ingredients and found it appropriate to extrapolate the existing information to conclude on the safety of all the tocopherols and tocotrienols.",

author = "Fiume, {Monice M.} and Bergfeld, {Wilma F.} and Belsito, {Donald V.} and Hill, {Ronald A.} and Klaassen, {Curtis D.} and Liebler, {Daniel C.} and Marks, {James G.} and Shank, {Ronald C.} and Slaga, {Thomas J.} and Snyder, {Paul W.} and Andersen, {F. Alan} and Bart Heldreth",

note = "Funding Information: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The articles in this supplement were sponsored by the Cosmetic Ingredient Review. The Cosmetic Ingredient Review is financially supported by the Personal Care Products Council. Publisher Copyright: {\textcopyright} The Author(s) 2018.",

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Safety Assessment of Tocopherols and Tocotrienols as Used in Cosmetics. / Fiume, Monice M.; Bergfeld, Wilma F.; Belsito, Donald V.; Hill, Ronald A.; Klaassen, Curtis D.; Liebler, Daniel C.; Marks, James G.; Shank, Ronald C.; Slaga, Thomas J.; Snyder, Paul W.; Andersen, F. Alan; Heldreth, Bart.

In: International journal of toxicology, Vol. 37, No. 2_suppl, 01.09.2018, p. 61S-94S.

Research output: Contribution to journal › Article › peer-review

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AU - Bergfeld, Wilma F.

AU - Belsito, Donald V.

AU - Hill, Ronald A.

AU - Klaassen, Curtis D.

AU - Liebler, Daniel C.

AU - Marks, James G.

AU - Shank, Ronald C.

AU - Slaga, Thomas J.

AU - Snyder, Paul W.

AU - Andersen, F. Alan

AU - Heldreth, Bart

N1 - Funding Information: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The articles in this supplement were sponsored by the Cosmetic Ingredient Review. The Cosmetic Ingredient Review is financially supported by the Personal Care Products Council. Publisher Copyright: © The Author(s) 2018.

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Safety Assessment of Tocopherols and Tocotrienols as Used in Cosmetics

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