Safety Assessment of Xylene Sulfonic Acid, Toluene Sulfonic Acid, and Alkyl Aryl Sulfonate Hydrotropes as Used in Cosmetics

Wilma F. Bergfeld, Donald V. Belsito, Curtis D. Klaassen, Ronald Hill, Daniel Liebler, James Marks, Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder, F. Alan Andersen

Research output: Contribution to journalReview article

Abstract

Xylene sulfonic acid, toluene sulfonic acid, and alkyl aryl sulfonate hydrotropes used in cosmetics as surfactants, hydrotropes, were reviewed in this safety assessment. The similar structure, properties, functions, and uses of these ingredients enabled grouping them and using the available toxicological data to assess the safety of the entire group. The Cosmetic Ingredient Review Expert Panel reviewed relevant animal and human data related to these ingredients. The panel concluded that xylene sulfonic acid and alkyl aryl sulfonate hydrotropes are safe as cosmetic ingredients in the present practices of use and concentrations as described in this safety assessment, when formulated to be nonirritating.

Original languageEnglish (US)
Pages (from-to)270S-283S
JournalInternational journal of toxicology
Volume30
DOIs
StatePublished - Jan 1 2011

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Arylsulfonates
Alkanesulfonates
Xylenes
Sulfonic Acids
Cosmetics
Toluene
Safety
Surface-Active Agents
Toxicology
Animals

All Science Journal Classification (ASJC) codes

  • Toxicology

Cite this

Bergfeld, Wilma F. ; Belsito, Donald V. ; Klaassen, Curtis D. ; Hill, Ronald ; Liebler, Daniel ; Marks, James ; Shank, Ronald C. ; Slaga, Thomas J. ; Snyder, Paul W. ; Andersen, F. Alan. / Safety Assessment of Xylene Sulfonic Acid, Toluene Sulfonic Acid, and Alkyl Aryl Sulfonate Hydrotropes as Used in Cosmetics. In: International journal of toxicology. 2011 ; Vol. 30. pp. 270S-283S.
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abstract = "Xylene sulfonic acid, toluene sulfonic acid, and alkyl aryl sulfonate hydrotropes used in cosmetics as surfactants, hydrotropes, were reviewed in this safety assessment. The similar structure, properties, functions, and uses of these ingredients enabled grouping them and using the available toxicological data to assess the safety of the entire group. The Cosmetic Ingredient Review Expert Panel reviewed relevant animal and human data related to these ingredients. The panel concluded that xylene sulfonic acid and alkyl aryl sulfonate hydrotropes are safe as cosmetic ingredients in the present practices of use and concentrations as described in this safety assessment, when formulated to be nonirritating.",
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Bergfeld, WF, Belsito, DV, Klaassen, CD, Hill, R, Liebler, D, Marks, J, Shank, RC, Slaga, TJ, Snyder, PW & Andersen, FA 2011, 'Safety Assessment of Xylene Sulfonic Acid, Toluene Sulfonic Acid, and Alkyl Aryl Sulfonate Hydrotropes as Used in Cosmetics', International journal of toxicology, vol. 30, pp. 270S-283S. https://doi.org/10.1177/1091581811429085

Safety Assessment of Xylene Sulfonic Acid, Toluene Sulfonic Acid, and Alkyl Aryl Sulfonate Hydrotropes as Used in Cosmetics. / Bergfeld, Wilma F.; Belsito, Donald V.; Klaassen, Curtis D.; Hill, Ronald; Liebler, Daniel; Marks, James; Shank, Ronald C.; Slaga, Thomas J.; Snyder, Paul W.; Andersen, F. Alan.

In: International journal of toxicology, Vol. 30, 01.01.2011, p. 270S-283S.

Research output: Contribution to journalReview article

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