Safety issues of maternal drug therapy during breastfeeding

Cheston Berlin, Ian Paul, E. S. Vesell

Research output: Contribution to journalComment/debatepeer-review

22 Scopus citations


Two goals when counseling breastfeeding mothers taking medication are protecting the infant from adverse events and permitting necessary maternal therapy. Madadi et al. report a case-control study of neonatal and maternal opioid toxicity after codeine administration. Therapeutic considerations in counseling breastfeeding mothers include susceptibility to drug toxicity of the very young and/or premature infant, significant interindividual variations in drug response, the dose-response relationship with respect to drug toxicity, and the role of pharmacogenetics in both the mother and the infant. These host factors may combine in a particular patient to act synergistically to produce an adverse reaction.

Original languageEnglish (US)
Pages (from-to)20-22
Number of pages3
JournalClinical pharmacology and therapeutics
Issue number1
StatePublished - Jan 1 2009

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)


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