Salivary cortisol reflects serum cortisol

Analysis of circadian profiles

Lorah D. Dorn, Joseph F. Lucke, Tammy L. Loucks, Sarah L. Berga

Research output: Contribution to journalArticle

94 Citations (Scopus)

Abstract

Background: Technical hurdles limit the characterization of key hormonal rhythms. Frequent sampling increases detection of changes in magnitude or circadian and ultradian patterns, but limits feasibility for clinical or research settings. These caveats are particularly pertinent for cortisol, a hormone that displays a prominent circadian rhythm and whose magnitude is tightly regulated in the absence of biobehavioural challenge. Ideally, one would like to obtain samples non-invasively from a matrix of interest at frequent intervals. While many investigations have reported a high correlation between serum and salivary cortisol assays, the degree to which salivary cortisol reflects the circadian patterns of circulating cortisol concentrations has not been established across a 24 h period. Methods: We obtained hourly serum and salivary samples over a 24 h period in nine adults in an inpatient setting. The circadian patterns for serum and salivary cortisol were analysed by harmonic regression. Results: For all but two subjects (both on oral contraceptives), the salivary cortisol concentration was synchronous with the serum concentration, indicating that the salivary assay could be substituted for the serum assay to assess circulating rhythmicity across the 24 h time frame. Conclusions: This statistical model has distinct improvement over the correlational approach of examining serum and saliva cortisol relationships. Saliva cortisol appears to represent serum cortisol across the 24 h period, except for those on oral contraceptives.

Original languageEnglish (US)
Pages (from-to)281-284
Number of pages4
JournalAnnals of Clinical Biochemistry
Volume44
Issue number3
DOIs
StatePublished - Jan 5 2007

Fingerprint

Hydrocortisone
Serum
Assays
Oral Contraceptives
Saliva
Statistical Models
Periodicity
Circadian Rhythm
Inpatients
Hormones
Sampling
Research

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry

Cite this

Dorn, Lorah D. ; Lucke, Joseph F. ; Loucks, Tammy L. ; Berga, Sarah L. / Salivary cortisol reflects serum cortisol : Analysis of circadian profiles. In: Annals of Clinical Biochemistry. 2007 ; Vol. 44, No. 3. pp. 281-284.
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Salivary cortisol reflects serum cortisol : Analysis of circadian profiles. / Dorn, Lorah D.; Lucke, Joseph F.; Loucks, Tammy L.; Berga, Sarah L.

In: Annals of Clinical Biochemistry, Vol. 44, No. 3, 05.01.2007, p. 281-284.

Research output: Contribution to journalArticle

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