Salivary gland disease in HIV/AIDS and primary Sjögren's Syndrome: Analysis of collagen I distribution and histopathology in American and African patients

Carole P. McArthur, Charlene W.J. Africa, William J. Castellani, Nida J. Luangjamekorn, Matthew McLaughlin, Antonio Subtil-DeOliveira, Charles Cobb, Paul Howard, Steven Gustafson, Dennis Palmer, Roberto N. Miranda

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Abstract

Background: Salivary gland disease (SGD) in HIV/AIDS is clinically and histopathologically very similar to Sjögren's Syndrome (SS), although the mechanism of tissue damage is unknown. The aim of this study is to determine the prevalence of SGD in primary SS and in HIV/AIDS in USA and in West African patients, and to seek distinguishing histopathologic features that may help to elucidate underlying mechanisms. Methods: Histologic sections of minor salivary glands from 164 HIV-positive and -negative patients from Cameroon and the US, and from 17 US patients with primary SS, were evaluated following salivary gland biopsy for inflammatory changes. To confirm the presence of fibrosis, collagen I, which is the most abundant collagen type, was assessed immunohistochemically in H&E-stained sections. Results: Forty-eight per cent of patients with HIV from Cameroon had severe SGD, while it was only in 6% of patients from the US. Patients with HIV in the US had less fibrosis and collagen I deposits than Cameroonians. Seventy-six per cent of US HIV-positive patients had received anti-retroviral therapy, while none of the African patients had. SS and AIDS patients had a tendency for lymphocytes to locate in a perivascular rather than in a periductal distribution. Conclusions: The prevalence of SGD and the presence of fibrosis and collagen I in Cameroonians with HIV is significantly higher than in HIV-positive American patients, and is similar to US patients with primary SS. The impact of patient selection, anti-retroviral therapy, and pathogenic mechanisms on salivary gland pathology is discussed.

Original languageEnglish (US)
Pages (from-to)544-551
Number of pages8
JournalJournal of Oral Pathology and Medicine
Volume32
Issue number9
DOIs
StatePublished - Oct 1 2003

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Salivary Gland Diseases
African Americans
Acquired Immunodeficiency Syndrome
Collagen
HIV
Cameroon
Fibrosis
Salivary Glands
Minor Salivary Glands
Patient Selection

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Oral Surgery
  • Otorhinolaryngology
  • Cancer Research
  • Periodontics

Cite this

McArthur, C. P., Africa, C. W. J., Castellani, W. J., Luangjamekorn, N. J., McLaughlin, M., Subtil-DeOliveira, A., ... Miranda, R. N. (2003). Salivary gland disease in HIV/AIDS and primary Sjögren's Syndrome: Analysis of collagen I distribution and histopathology in American and African patients. Journal of Oral Pathology and Medicine, 32(9), 544-551. https://doi.org/10.1034/j.1600-0714.2003.00159.x
McArthur, Carole P. ; Africa, Charlene W.J. ; Castellani, William J. ; Luangjamekorn, Nida J. ; McLaughlin, Matthew ; Subtil-DeOliveira, Antonio ; Cobb, Charles ; Howard, Paul ; Gustafson, Steven ; Palmer, Dennis ; Miranda, Roberto N. / Salivary gland disease in HIV/AIDS and primary Sjögren's Syndrome : Analysis of collagen I distribution and histopathology in American and African patients. In: Journal of Oral Pathology and Medicine. 2003 ; Vol. 32, No. 9. pp. 544-551.
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abstract = "Background: Salivary gland disease (SGD) in HIV/AIDS is clinically and histopathologically very similar to Sj{\"o}gren's Syndrome (SS), although the mechanism of tissue damage is unknown. The aim of this study is to determine the prevalence of SGD in primary SS and in HIV/AIDS in USA and in West African patients, and to seek distinguishing histopathologic features that may help to elucidate underlying mechanisms. Methods: Histologic sections of minor salivary glands from 164 HIV-positive and -negative patients from Cameroon and the US, and from 17 US patients with primary SS, were evaluated following salivary gland biopsy for inflammatory changes. To confirm the presence of fibrosis, collagen I, which is the most abundant collagen type, was assessed immunohistochemically in H&E-stained sections. Results: Forty-eight per cent of patients with HIV from Cameroon had severe SGD, while it was only in 6{\%} of patients from the US. Patients with HIV in the US had less fibrosis and collagen I deposits than Cameroonians. Seventy-six per cent of US HIV-positive patients had received anti-retroviral therapy, while none of the African patients had. SS and AIDS patients had a tendency for lymphocytes to locate in a perivascular rather than in a periductal distribution. Conclusions: The prevalence of SGD and the presence of fibrosis and collagen I in Cameroonians with HIV is significantly higher than in HIV-positive American patients, and is similar to US patients with primary SS. The impact of patient selection, anti-retroviral therapy, and pathogenic mechanisms on salivary gland pathology is discussed.",
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McArthur, CP, Africa, CWJ, Castellani, WJ, Luangjamekorn, NJ, McLaughlin, M, Subtil-DeOliveira, A, Cobb, C, Howard, P, Gustafson, S, Palmer, D & Miranda, RN 2003, 'Salivary gland disease in HIV/AIDS and primary Sjögren's Syndrome: Analysis of collagen I distribution and histopathology in American and African patients', Journal of Oral Pathology and Medicine, vol. 32, no. 9, pp. 544-551. https://doi.org/10.1034/j.1600-0714.2003.00159.x

Salivary gland disease in HIV/AIDS and primary Sjögren's Syndrome : Analysis of collagen I distribution and histopathology in American and African patients. / McArthur, Carole P.; Africa, Charlene W.J.; Castellani, William J.; Luangjamekorn, Nida J.; McLaughlin, Matthew; Subtil-DeOliveira, Antonio; Cobb, Charles; Howard, Paul; Gustafson, Steven; Palmer, Dennis; Miranda, Roberto N.

In: Journal of Oral Pathology and Medicine, Vol. 32, No. 9, 01.10.2003, p. 544-551.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Salivary gland disease in HIV/AIDS and primary Sjögren's Syndrome

T2 - Analysis of collagen I distribution and histopathology in American and African patients

AU - McArthur, Carole P.

AU - Africa, Charlene W.J.

AU - Castellani, William J.

AU - Luangjamekorn, Nida J.

AU - McLaughlin, Matthew

AU - Subtil-DeOliveira, Antonio

AU - Cobb, Charles

AU - Howard, Paul

AU - Gustafson, Steven

AU - Palmer, Dennis

AU - Miranda, Roberto N.

PY - 2003/10/1

Y1 - 2003/10/1

N2 - Background: Salivary gland disease (SGD) in HIV/AIDS is clinically and histopathologically very similar to Sjögren's Syndrome (SS), although the mechanism of tissue damage is unknown. The aim of this study is to determine the prevalence of SGD in primary SS and in HIV/AIDS in USA and in West African patients, and to seek distinguishing histopathologic features that may help to elucidate underlying mechanisms. Methods: Histologic sections of minor salivary glands from 164 HIV-positive and -negative patients from Cameroon and the US, and from 17 US patients with primary SS, were evaluated following salivary gland biopsy for inflammatory changes. To confirm the presence of fibrosis, collagen I, which is the most abundant collagen type, was assessed immunohistochemically in H&E-stained sections. Results: Forty-eight per cent of patients with HIV from Cameroon had severe SGD, while it was only in 6% of patients from the US. Patients with HIV in the US had less fibrosis and collagen I deposits than Cameroonians. Seventy-six per cent of US HIV-positive patients had received anti-retroviral therapy, while none of the African patients had. SS and AIDS patients had a tendency for lymphocytes to locate in a perivascular rather than in a periductal distribution. Conclusions: The prevalence of SGD and the presence of fibrosis and collagen I in Cameroonians with HIV is significantly higher than in HIV-positive American patients, and is similar to US patients with primary SS. The impact of patient selection, anti-retroviral therapy, and pathogenic mechanisms on salivary gland pathology is discussed.

AB - Background: Salivary gland disease (SGD) in HIV/AIDS is clinically and histopathologically very similar to Sjögren's Syndrome (SS), although the mechanism of tissue damage is unknown. The aim of this study is to determine the prevalence of SGD in primary SS and in HIV/AIDS in USA and in West African patients, and to seek distinguishing histopathologic features that may help to elucidate underlying mechanisms. Methods: Histologic sections of minor salivary glands from 164 HIV-positive and -negative patients from Cameroon and the US, and from 17 US patients with primary SS, were evaluated following salivary gland biopsy for inflammatory changes. To confirm the presence of fibrosis, collagen I, which is the most abundant collagen type, was assessed immunohistochemically in H&E-stained sections. Results: Forty-eight per cent of patients with HIV from Cameroon had severe SGD, while it was only in 6% of patients from the US. Patients with HIV in the US had less fibrosis and collagen I deposits than Cameroonians. Seventy-six per cent of US HIV-positive patients had received anti-retroviral therapy, while none of the African patients had. SS and AIDS patients had a tendency for lymphocytes to locate in a perivascular rather than in a periductal distribution. Conclusions: The prevalence of SGD and the presence of fibrosis and collagen I in Cameroonians with HIV is significantly higher than in HIV-positive American patients, and is similar to US patients with primary SS. The impact of patient selection, anti-retroviral therapy, and pathogenic mechanisms on salivary gland pathology is discussed.

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