Salt-responsive polyzwitterionic materials for surface regeneration between switchable fouling and antifouling properties

Hong Chen, Jintao Yang, Shengwei Xiao, Rundong Hu, Sarang M. Bhaway, Bryan D. Vogt, Mingzhen Zhang, Qiang Chen, Jie Ma, Yung Chang, Lingyan Li, Jie Zheng

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Abstract

Development of smart regenerative surface is a highly challenging but important task for many scientific and industrial applications. Specifically, very limited research efforts were made for surface regeneration between bio-adhesion and antifouling properties, because bioadhesion and antifouling are the two highly desirable but completely opposite properties of materials. Herein, we developed salt-responsive polymer brushes of poly(3-(1-(4-vinylbenzyl)-1H-imidazol-3-ium-3-yl) propane-1-sulfonate) (polyVBIPS), which can be switched reversibly and repeatedly between protein capture/release and surface wettability in a controllable manner. PolyVBIPS brush has demonstrated its switching ability to resist both protein adsorption from 100% blood plasma/serum and bacterial attachment in multiple cycles. PolyVBIPS brush also exhibits reversible surface wettability from ∼40° to 25° between in PBS and in 1 M NaCl solutions in multiple cycles. Overall, the salt-responsive behaviors of polyVBIPS brushes can be interpreted by the “anti-polyelectrolyte effect”, i.e. polyVBIPS brushes adopt a collapsed chain conformation at low ionic strengths to achieve surface adhesive, but an extended chain conformation at high ionic strength to realize antifouling properties. We expect that polyVBIPS will provide a simple, robust, and promising system for the fabrication of smart surfaces with biocompatible, reliable, and regenerative properties. Statement of Significance Unlike many materials with “one-time switching” capability for surface regeneration, we developed a new regenerative surface of zwitterionic polymer brush, which exhibits a reversible salt-induced switching property between a biomolecule-adhesive state and a biomolecule repellent state in complex media for multiple cycles. PolyVBIPS is easily synthesized and can be straightforward coated on the surface, which provides a simple, robust, and promising system for the fabrication of smart surfaces with biocompatible, reliable, regenerative properties.

Original languageEnglish (US)
Pages (from-to)62-69
Number of pages8
JournalActa Biomaterialia
Volume40
DOIs
StatePublished - Aug 1 2016

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All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biomaterials
  • Biochemistry
  • Biomedical Engineering
  • Molecular Biology

Cite this

Chen, H., Yang, J., Xiao, S., Hu, R., Bhaway, S. M., Vogt, B. D., Zhang, M., Chen, Q., Ma, J., Chang, Y., Li, L., & Zheng, J. (2016). Salt-responsive polyzwitterionic materials for surface regeneration between switchable fouling and antifouling properties. Acta Biomaterialia, 40, 62-69. https://doi.org/10.1016/j.actbio.2016.03.009