Salvage of occluded arterial bypass grafts by means of thrombolysis

Geoffrey A. Gardiner, Donald P. Harrington, Walter Koltun, Anthony Whittemore, John A. Mannick, David C. Levin

Research output: Contribution to journalArticle

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Abstract

Seventy-two thrombosed peripheral arterial bypass grafts in 62 patients were treated by local intraarterial thrombolytic infusion. The initial success rate was 69% (50 of 72 grafts). Graft material and location had no significant effect on the initial results. Urokinase was used in 43 cases with a 84% success rate, and streptokinase was used in 29 cases with a 48% success rate. After a follow-up period that ranged from 2 to 58 months, 27 grafts remained patent, with an average patency duration of 15 months (median 8 months). Overall graft patency at the end of 1 year was 60% applying life-table analysis. Factors that were evaluated to determine their effect on long-term patency included graft age and material, graft location, and the presence or absence of an underlying correctable lesion. The most significant factor in long-term patency was the presence of a lesion that was correctable by surgical revision or balloon angioplasty. In 25 grafts with underlying stenotic lesions, the 1-year patency was 86% after successful treatment. Twenty-five grafts without detectable lesions had 37% 1-year patency. (J Vasc Surg 1989;9:426–31.)

Original languageEnglish (US)
Pages (from-to)426-431
Number of pages6
JournalJournal of Vascular Surgery
Volume9
Issue number3
DOIs
StatePublished - Jan 1 1989

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Transplants
Intra Arterial Infusions
Life Tables
Streptokinase
Balloon Angioplasty
Urokinase-Type Plasminogen Activator
Reoperation
Thrombosis

All Science Journal Classification (ASJC) codes

  • Surgery
  • Cardiology and Cardiovascular Medicine

Cite this

Gardiner, G. A., Harrington, D. P., Koltun, W., Whittemore, A., Mannick, J. A., & Levin, D. C. (1989). Salvage of occluded arterial bypass grafts by means of thrombolysis. Journal of Vascular Surgery, 9(3), 426-431. https://doi.org/10.1016/S0741-5214(89)70005-7
Gardiner, Geoffrey A. ; Harrington, Donald P. ; Koltun, Walter ; Whittemore, Anthony ; Mannick, John A. ; Levin, David C. / Salvage of occluded arterial bypass grafts by means of thrombolysis. In: Journal of Vascular Surgery. 1989 ; Vol. 9, No. 3. pp. 426-431.
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Gardiner, GA, Harrington, DP, Koltun, W, Whittemore, A, Mannick, JA & Levin, DC 1989, 'Salvage of occluded arterial bypass grafts by means of thrombolysis', Journal of Vascular Surgery, vol. 9, no. 3, pp. 426-431. https://doi.org/10.1016/S0741-5214(89)70005-7

Salvage of occluded arterial bypass grafts by means of thrombolysis. / Gardiner, Geoffrey A.; Harrington, Donald P.; Koltun, Walter; Whittemore, Anthony; Mannick, John A.; Levin, David C.

In: Journal of Vascular Surgery, Vol. 9, No. 3, 01.01.1989, p. 426-431.

Research output: Contribution to journalArticle

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