Sample size considerations for assessing individual bioequivalence based on the method of tolerance intervals

J. D. Esinhart, Vernon Chinchilli

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Abstract

This is the consideration of sample sizes for assessing individual bioequivalence based on the use of tolerance intervals. The sample size procedures discussed include a direct distribution-free method, indirect parametric method and a direct parametric method. Design considerations are discussed based on the results of the direct parametric method. Tables are provided for easy access of results.

Original languageEnglish (US)
Pages (from-to)26-32
Number of pages7
JournalInternational Journal of Clinical Pharmacology Therapy and Toxicology
Volume32
Issue number1
Publication statusPublished - Jan 1 1994

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All Science Journal Classification (ASJC) codes

  • Toxicology
  • Pharmacology (medical)

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