Sarcopenia in Peripheral Arterial Disease: Prevalence and Effect on Functional Status

Odessa Addison, Steven J. Prior, Rishi Kundi, Monica C. Serra, Leslie I. Katzel, Andrew Gardner, Alice S. Ryan

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objectives: (1) To determine the prevalence of sarcopenia in older men with peripheral arterial disease (PAD); (2) to compare a subgroup of the group with age-, race-, sex-, and body mass index (BMI)–matched non-PAD control counterparts, and (3) to compare the functional status of those with PAD with and without sarcopenia. Design: Cohort study. Setting: Medical center. Participants: Sedentary community-dwelling men (N=108; age, >50y) with a confirmed diagnosis of PAD (44% blacks; BMI, 27.8±0.4kg/m2; ankle-brachial index,.62±.01). Interventions: Not applicable. Main Outcome Measures: Dual-energy x-ray absorptiometry scans were used to assess appendicular lean mass and determine the prevalence of sarcopenia by/height2. Treadmill tests were used to determine claudication onset time, peak walking time, and claudication recovery time. 6-Minute walk distance was also measured. Results: Sarcopenia prevalence in our PAD cohort was 25%. The PAD subgroup (n=42) matched with control counterparts in terms of race, sex, age, and BMI had higher prevalence rates than did their non-PAD counterparts (23.8% vs 2.4%; P<.05). Individuals with sarcopenia (n=28) had a shorter 6-minute walk distance (326±18.8m vs 380±9.7m; P<.05) and higher claudication recovery time (592±98s vs 395±29s; P<.05) than did individuals with PAD but without sarcopenia (n=80). There was no difference in claudication onset time or peak walking time between the PAD groups. Conclusions: Men with PAD demonstrate a high prevalence of sarcopenia. Those with sarcopenia and PAD demonstrate decreased mobility function.

Original languageEnglish (US)
Pages (from-to)623-628
Number of pages6
JournalArchives of Physical Medicine and Rehabilitation
Volume99
Issue number4
DOIs
StatePublished - Apr 1 2018

Fingerprint

Sarcopenia
Peripheral Arterial Disease
Body Mass Index
Walking
Independent Living
Ankle Brachial Index
Exercise Test
Cohort Studies
Age Groups
X-Rays
Outcome Assessment (Health Care)

All Science Journal Classification (ASJC) codes

  • Physical Therapy, Sports Therapy and Rehabilitation
  • Rehabilitation

Cite this

Addison, Odessa ; Prior, Steven J. ; Kundi, Rishi ; Serra, Monica C. ; Katzel, Leslie I. ; Gardner, Andrew ; Ryan, Alice S. / Sarcopenia in Peripheral Arterial Disease : Prevalence and Effect on Functional Status. In: Archives of Physical Medicine and Rehabilitation. 2018 ; Vol. 99, No. 4. pp. 623-628.
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abstract = "Objectives: (1) To determine the prevalence of sarcopenia in older men with peripheral arterial disease (PAD); (2) to compare a subgroup of the group with age-, race-, sex-, and body mass index (BMI)–matched non-PAD control counterparts, and (3) to compare the functional status of those with PAD with and without sarcopenia. Design: Cohort study. Setting: Medical center. Participants: Sedentary community-dwelling men (N=108; age, >50y) with a confirmed diagnosis of PAD (44{\%} blacks; BMI, 27.8±0.4kg/m2; ankle-brachial index,.62±.01). Interventions: Not applicable. Main Outcome Measures: Dual-energy x-ray absorptiometry scans were used to assess appendicular lean mass and determine the prevalence of sarcopenia by/height2. Treadmill tests were used to determine claudication onset time, peak walking time, and claudication recovery time. 6-Minute walk distance was also measured. Results: Sarcopenia prevalence in our PAD cohort was 25{\%}. The PAD subgroup (n=42) matched with control counterparts in terms of race, sex, age, and BMI had higher prevalence rates than did their non-PAD counterparts (23.8{\%} vs 2.4{\%}; P<.05). Individuals with sarcopenia (n=28) had a shorter 6-minute walk distance (326±18.8m vs 380±9.7m; P<.05) and higher claudication recovery time (592±98s vs 395±29s; P<.05) than did individuals with PAD but without sarcopenia (n=80). There was no difference in claudication onset time or peak walking time between the PAD groups. Conclusions: Men with PAD demonstrate a high prevalence of sarcopenia. Those with sarcopenia and PAD demonstrate decreased mobility function.",
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Sarcopenia in Peripheral Arterial Disease : Prevalence and Effect on Functional Status. / Addison, Odessa; Prior, Steven J.; Kundi, Rishi; Serra, Monica C.; Katzel, Leslie I.; Gardner, Andrew; Ryan, Alice S.

In: Archives of Physical Medicine and Rehabilitation, Vol. 99, No. 4, 01.04.2018, p. 623-628.

Research output: Contribution to journalArticle

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T1 - Sarcopenia in Peripheral Arterial Disease

T2 - Prevalence and Effect on Functional Status

AU - Addison, Odessa

AU - Prior, Steven J.

AU - Kundi, Rishi

AU - Serra, Monica C.

AU - Katzel, Leslie I.

AU - Gardner, Andrew

AU - Ryan, Alice S.

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N2 - Objectives: (1) To determine the prevalence of sarcopenia in older men with peripheral arterial disease (PAD); (2) to compare a subgroup of the group with age-, race-, sex-, and body mass index (BMI)–matched non-PAD control counterparts, and (3) to compare the functional status of those with PAD with and without sarcopenia. Design: Cohort study. Setting: Medical center. Participants: Sedentary community-dwelling men (N=108; age, >50y) with a confirmed diagnosis of PAD (44% blacks; BMI, 27.8±0.4kg/m2; ankle-brachial index,.62±.01). Interventions: Not applicable. Main Outcome Measures: Dual-energy x-ray absorptiometry scans were used to assess appendicular lean mass and determine the prevalence of sarcopenia by/height2. Treadmill tests were used to determine claudication onset time, peak walking time, and claudication recovery time. 6-Minute walk distance was also measured. Results: Sarcopenia prevalence in our PAD cohort was 25%. The PAD subgroup (n=42) matched with control counterparts in terms of race, sex, age, and BMI had higher prevalence rates than did their non-PAD counterparts (23.8% vs 2.4%; P<.05). Individuals with sarcopenia (n=28) had a shorter 6-minute walk distance (326±18.8m vs 380±9.7m; P<.05) and higher claudication recovery time (592±98s vs 395±29s; P<.05) than did individuals with PAD but without sarcopenia (n=80). There was no difference in claudication onset time or peak walking time between the PAD groups. Conclusions: Men with PAD demonstrate a high prevalence of sarcopenia. Those with sarcopenia and PAD demonstrate decreased mobility function.

AB - Objectives: (1) To determine the prevalence of sarcopenia in older men with peripheral arterial disease (PAD); (2) to compare a subgroup of the group with age-, race-, sex-, and body mass index (BMI)–matched non-PAD control counterparts, and (3) to compare the functional status of those with PAD with and without sarcopenia. Design: Cohort study. Setting: Medical center. Participants: Sedentary community-dwelling men (N=108; age, >50y) with a confirmed diagnosis of PAD (44% blacks; BMI, 27.8±0.4kg/m2; ankle-brachial index,.62±.01). Interventions: Not applicable. Main Outcome Measures: Dual-energy x-ray absorptiometry scans were used to assess appendicular lean mass and determine the prevalence of sarcopenia by/height2. Treadmill tests were used to determine claudication onset time, peak walking time, and claudication recovery time. 6-Minute walk distance was also measured. Results: Sarcopenia prevalence in our PAD cohort was 25%. The PAD subgroup (n=42) matched with control counterparts in terms of race, sex, age, and BMI had higher prevalence rates than did their non-PAD counterparts (23.8% vs 2.4%; P<.05). Individuals with sarcopenia (n=28) had a shorter 6-minute walk distance (326±18.8m vs 380±9.7m; P<.05) and higher claudication recovery time (592±98s vs 395±29s; P<.05) than did individuals with PAD but without sarcopenia (n=80). There was no difference in claudication onset time or peak walking time between the PAD groups. Conclusions: Men with PAD demonstrate a high prevalence of sarcopenia. Those with sarcopenia and PAD demonstrate decreased mobility function.

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