SBR-Blood: Systems biology repository for hematopoietic cells

Jens Lichtenberg, Elisabeth F. Heuston, Tejaswini Mishra, Cheryl A. Keller, Ross C. Hardison, David M. Bodine

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Extensive research into hematopoiesis (the development of blood cells) over several decades has generated large sets of expression and epigenetic profiles in multiple human and mouse blood cell types. However, there is no single location to analyze how gene regulatory processes lead to different mature blood cells. We have developed a new database framework called hematopoietic Systems Biology Repository (SBR-Blood), available online at http://sbrblood.nhgri.nih.gov, which allows userinitiated analyses for cell type correlations or genespecific behavior during differentiation using publicly available datasets for array- and sequencingbased platforms from mouse hematopoietic cells. SBR-Blood organizes information by both cell identity and by hematopoietic lineage. The validity and usability of SBR-Blood has been established through the reproduction of workflows relevant to expression data, DNA methylation, histone modifications and transcription factor occupancy profiles.

Original languageEnglish (US)
Pages (from-to)D925-D931
JournalNucleic acids research
Volume44
Issue numberD1
DOIs
StatePublished - 2016

All Science Journal Classification (ASJC) codes

  • Genetics

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