Scaffolds of Biodegradable Block Polyurethanes for Nerve Regeneration

K. T. Xu, Y. Q. Niu, Y. H. Zhu, X. Y. Liu, C. Liu

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Two types of biodegradable block polyurethanes based on polycaprolactone (PCL) and poly(ethylene glycol) (PEG) were prepared by controlling the regularity of block arrangements, that is, alternating block polyurethanes PUCL-. alt-PEG. Traditional random block polyurethanes PUCL-. ran-PEG were also prepared for comparison. Nerve repair scaffolds were prepared from these block polyurethanes. The nerve repair scaffolds were tested in a Sprague-Dawley rat peripheral nerve defect model. The nerve regeneration was evaluated by sciatic function index analysis and histological analyses. Results revealed that polyurethane nerve-guided scaffolds exhibited much greater regeneration capabilities than PCL. Particularly, PUCL-. alt-PEG exhibited better nerve regeneration than the autograft. These studies warrant further studies toward optimization of the block polyurethane nerve-guided scaffolds for peripheral nerve regeneration.

Original languageEnglish (US)
Title of host publicationAdvances in Polyurethane Biomaterials
PublisherElsevier Inc.
Pages599-629
Number of pages31
ISBN (Electronic)9780081006221
ISBN (Print)9780081006146
DOIs
StatePublished - Feb 2 2016

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Health Professions(all)

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    Xu, K. T., Niu, Y. Q., Zhu, Y. H., Liu, X. Y., & Liu, C. (2016). Scaffolds of Biodegradable Block Polyurethanes for Nerve Regeneration. In Advances in Polyurethane Biomaterials (pp. 599-629). Elsevier Inc.. https://doi.org/10.1016/B978-0-08-100614-6.00021-4