SCORE Study Report 1: Baseline Associations between Central Retinal Thickness and Visual Acuity in Patients with Retinal Vein Occlusion

Ingrid Scott, Paul C. VanVeldhuisen, Neal L. Oden, Michael S. Ip, Barbara A. Blodi, J. Michael Jumper, Maria Figueroa

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Abstract

Objective: To investigate the relationship between baseline center point retinal thickness measured by optical coherence tomography (OCT) and best-corrected visual acuity in eyes with macular edema associated with retinal vein occlusion and to investigate other factors associated with baseline visual acuity letter score. Design: The Standard Care versus COrticosteroid for REtinal Vein Occlusion (SCORE) Study includes 2 multicenter, randomized clinical trials: one evaluating participants with central retinal vein occlusion (CRVO) and the other evaluating participants with branch retinal vein occlusion (BRVO). Participants: After omitting 17 participants with missing or unreliable OCT measurements, analyses proceeded with 665 enrolled SCORE Study participants (665 eyes), including 262 with CRVO and 403 with BRVO. Methods: At baseline, center point thickness was measured by OCT (Stratus OCT 3 [n = 663] and OCT2 [n = 2]; Carl Zeiss Meditech, Dublin, CA), and visual acuity was measured by the electronic Early Treatment Diabetic Retinopathy Study (E-ETDRS) methodology. Main Outcome Measures: Center point thickness and best-corrected E-ETDRS visual acuity letter score. Results: The correlation coefficient for the association between baseline OCT-measured center point thickness and best-corrected E-ETDRS visual acuity letter score is -0.27 (95% confidence limit: -0.38 to -0.16) for participants in the CRVO trial and -0.28 (95% confidence limit: -0.37 to -0.19) in the BRVO trial. Regression modeling estimated the following decrease in baseline visual acuity letter score for every 100-μm increase in OCT-measured center point thickness: 1.7 letters (P = 0.0007) for CRVO and 1.9 letters (P<0.0001) for BRVO. On the basis of multivariate regression models, baseline factors significantly associated (P<0.05, after adjusting for multiple testing) with baseline visual acuity letter score include age and duration of macular edema for CRVO participants and center point thickness and presence of cystoid spaces for BRVO participants. Conclusions: The correlation between OCT-measured center point thickness and visual acuity letter score is modest. OCT-measured center point thickness represents a useful tool for the detection and monitoring of macular edema in retinal vein occlusion, but it cannot reliably substitute for visual acuity measurements. Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article.

Original languageEnglish (US)
Pages (from-to)504-512
Number of pages9
JournalOphthalmology
Volume116
Issue number3
DOIs
StatePublished - Mar 1 2009

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Retinal Vein Occlusion
Visual Acuity
Optical Coherence Tomography
Retinal Vein
Macular Edema
Diabetic Retinopathy
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All Science Journal Classification (ASJC) codes

  • Ophthalmology

Cite this

Scott, Ingrid ; VanVeldhuisen, Paul C. ; Oden, Neal L. ; Ip, Michael S. ; Blodi, Barbara A. ; Jumper, J. Michael ; Figueroa, Maria. / SCORE Study Report 1 : Baseline Associations between Central Retinal Thickness and Visual Acuity in Patients with Retinal Vein Occlusion. In: Ophthalmology. 2009 ; Vol. 116, No. 3. pp. 504-512.
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title = "SCORE Study Report 1: Baseline Associations between Central Retinal Thickness and Visual Acuity in Patients with Retinal Vein Occlusion",
abstract = "Objective: To investigate the relationship between baseline center point retinal thickness measured by optical coherence tomography (OCT) and best-corrected visual acuity in eyes with macular edema associated with retinal vein occlusion and to investigate other factors associated with baseline visual acuity letter score. Design: The Standard Care versus COrticosteroid for REtinal Vein Occlusion (SCORE) Study includes 2 multicenter, randomized clinical trials: one evaluating participants with central retinal vein occlusion (CRVO) and the other evaluating participants with branch retinal vein occlusion (BRVO). Participants: After omitting 17 participants with missing or unreliable OCT measurements, analyses proceeded with 665 enrolled SCORE Study participants (665 eyes), including 262 with CRVO and 403 with BRVO. Methods: At baseline, center point thickness was measured by OCT (Stratus OCT 3 [n = 663] and OCT2 [n = 2]; Carl Zeiss Meditech, Dublin, CA), and visual acuity was measured by the electronic Early Treatment Diabetic Retinopathy Study (E-ETDRS) methodology. Main Outcome Measures: Center point thickness and best-corrected E-ETDRS visual acuity letter score. Results: The correlation coefficient for the association between baseline OCT-measured center point thickness and best-corrected E-ETDRS visual acuity letter score is -0.27 (95{\%} confidence limit: -0.38 to -0.16) for participants in the CRVO trial and -0.28 (95{\%} confidence limit: -0.37 to -0.19) in the BRVO trial. Regression modeling estimated the following decrease in baseline visual acuity letter score for every 100-μm increase in OCT-measured center point thickness: 1.7 letters (P = 0.0007) for CRVO and 1.9 letters (P<0.0001) for BRVO. On the basis of multivariate regression models, baseline factors significantly associated (P<0.05, after adjusting for multiple testing) with baseline visual acuity letter score include age and duration of macular edema for CRVO participants and center point thickness and presence of cystoid spaces for BRVO participants. Conclusions: The correlation between OCT-measured center point thickness and visual acuity letter score is modest. OCT-measured center point thickness represents a useful tool for the detection and monitoring of macular edema in retinal vein occlusion, but it cannot reliably substitute for visual acuity measurements. Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article.",
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SCORE Study Report 1 : Baseline Associations between Central Retinal Thickness and Visual Acuity in Patients with Retinal Vein Occlusion. / Scott, Ingrid; VanVeldhuisen, Paul C.; Oden, Neal L.; Ip, Michael S.; Blodi, Barbara A.; Jumper, J. Michael; Figueroa, Maria.

In: Ophthalmology, Vol. 116, No. 3, 01.03.2009, p. 504-512.

Research output: Contribution to journalArticle

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T2 - Baseline Associations between Central Retinal Thickness and Visual Acuity in Patients with Retinal Vein Occlusion

AU - Scott, Ingrid

AU - VanVeldhuisen, Paul C.

AU - Oden, Neal L.

AU - Ip, Michael S.

AU - Blodi, Barbara A.

AU - Jumper, J. Michael

AU - Figueroa, Maria

PY - 2009/3/1

Y1 - 2009/3/1

N2 - Objective: To investigate the relationship between baseline center point retinal thickness measured by optical coherence tomography (OCT) and best-corrected visual acuity in eyes with macular edema associated with retinal vein occlusion and to investigate other factors associated with baseline visual acuity letter score. Design: The Standard Care versus COrticosteroid for REtinal Vein Occlusion (SCORE) Study includes 2 multicenter, randomized clinical trials: one evaluating participants with central retinal vein occlusion (CRVO) and the other evaluating participants with branch retinal vein occlusion (BRVO). Participants: After omitting 17 participants with missing or unreliable OCT measurements, analyses proceeded with 665 enrolled SCORE Study participants (665 eyes), including 262 with CRVO and 403 with BRVO. Methods: At baseline, center point thickness was measured by OCT (Stratus OCT 3 [n = 663] and OCT2 [n = 2]; Carl Zeiss Meditech, Dublin, CA), and visual acuity was measured by the electronic Early Treatment Diabetic Retinopathy Study (E-ETDRS) methodology. Main Outcome Measures: Center point thickness and best-corrected E-ETDRS visual acuity letter score. Results: The correlation coefficient for the association between baseline OCT-measured center point thickness and best-corrected E-ETDRS visual acuity letter score is -0.27 (95% confidence limit: -0.38 to -0.16) for participants in the CRVO trial and -0.28 (95% confidence limit: -0.37 to -0.19) in the BRVO trial. Regression modeling estimated the following decrease in baseline visual acuity letter score for every 100-μm increase in OCT-measured center point thickness: 1.7 letters (P = 0.0007) for CRVO and 1.9 letters (P<0.0001) for BRVO. On the basis of multivariate regression models, baseline factors significantly associated (P<0.05, after adjusting for multiple testing) with baseline visual acuity letter score include age and duration of macular edema for CRVO participants and center point thickness and presence of cystoid spaces for BRVO participants. Conclusions: The correlation between OCT-measured center point thickness and visual acuity letter score is modest. OCT-measured center point thickness represents a useful tool for the detection and monitoring of macular edema in retinal vein occlusion, but it cannot reliably substitute for visual acuity measurements. Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article.

AB - Objective: To investigate the relationship between baseline center point retinal thickness measured by optical coherence tomography (OCT) and best-corrected visual acuity in eyes with macular edema associated with retinal vein occlusion and to investigate other factors associated with baseline visual acuity letter score. Design: The Standard Care versus COrticosteroid for REtinal Vein Occlusion (SCORE) Study includes 2 multicenter, randomized clinical trials: one evaluating participants with central retinal vein occlusion (CRVO) and the other evaluating participants with branch retinal vein occlusion (BRVO). Participants: After omitting 17 participants with missing or unreliable OCT measurements, analyses proceeded with 665 enrolled SCORE Study participants (665 eyes), including 262 with CRVO and 403 with BRVO. Methods: At baseline, center point thickness was measured by OCT (Stratus OCT 3 [n = 663] and OCT2 [n = 2]; Carl Zeiss Meditech, Dublin, CA), and visual acuity was measured by the electronic Early Treatment Diabetic Retinopathy Study (E-ETDRS) methodology. Main Outcome Measures: Center point thickness and best-corrected E-ETDRS visual acuity letter score. Results: The correlation coefficient for the association between baseline OCT-measured center point thickness and best-corrected E-ETDRS visual acuity letter score is -0.27 (95% confidence limit: -0.38 to -0.16) for participants in the CRVO trial and -0.28 (95% confidence limit: -0.37 to -0.19) in the BRVO trial. Regression modeling estimated the following decrease in baseline visual acuity letter score for every 100-μm increase in OCT-measured center point thickness: 1.7 letters (P = 0.0007) for CRVO and 1.9 letters (P<0.0001) for BRVO. On the basis of multivariate regression models, baseline factors significantly associated (P<0.05, after adjusting for multiple testing) with baseline visual acuity letter score include age and duration of macular edema for CRVO participants and center point thickness and presence of cystoid spaces for BRVO participants. Conclusions: The correlation between OCT-measured center point thickness and visual acuity letter score is modest. OCT-measured center point thickness represents a useful tool for the detection and monitoring of macular edema in retinal vein occlusion, but it cannot reliably substitute for visual acuity measurements. Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article.

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