Structures of the clamp loader-clamp complex reveal that nature uses machined parts in the form of a spiral scaffold (the clamp loader) to thread a circlet (the clamp) on a helix of DNA. The scaffold is then replaced by an interpretive copying machine, the polymerase, to eventually generate the replisome for DNA replication.
All Science Journal Classification (ASJC) codes
- Structural Biology
- Molecular Biology