'Screw-cap' clamp loader proteins that thread

Zhihao Zhuang, Michelle Marie Spiering, Anthony J. Berdis, Michael A. Trakselis, Stephen Benkovic

Research output: Contribution to journalShort survey

3 Citations (Scopus)

Abstract

Structures of the clamp loader-clamp complex reveal that nature uses machined parts in the form of a spiral scaffold (the clamp loader) to thread a circlet (the clamp) on a helix of DNA. The scaffold is then replaced by an interpretive copying machine, the polymerase, to eventually generate the replisome for DNA replication.

Original languageEnglish (US)
Pages (from-to)580-581
Number of pages2
JournalNature Structural and Molecular Biology
Volume11
Issue number7
DOIs
StatePublished - Jul 1 2004

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DNA Replication
DNA
Proteins

All Science Journal Classification (ASJC) codes

  • Structural Biology
  • Molecular Biology

Cite this

Zhuang, Zhihao ; Spiering, Michelle Marie ; Berdis, Anthony J. ; Trakselis, Michael A. ; Benkovic, Stephen. / 'Screw-cap' clamp loader proteins that thread. In: Nature Structural and Molecular Biology. 2004 ; Vol. 11, No. 7. pp. 580-581.
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Zhuang, Z, Spiering, MM, Berdis, AJ, Trakselis, MA & Benkovic, S 2004, ''Screw-cap' clamp loader proteins that thread', Nature Structural and Molecular Biology, vol. 11, no. 7, pp. 580-581. https://doi.org/10.1038/nsmb0704-580

'Screw-cap' clamp loader proteins that thread. / Zhuang, Zhihao; Spiering, Michelle Marie; Berdis, Anthony J.; Trakselis, Michael A.; Benkovic, Stephen.

In: Nature Structural and Molecular Biology, Vol. 11, No. 7, 01.07.2004, p. 580-581.

Research output: Contribution to journalShort survey

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