Searching for the polycystic ovary syndrome genes

M. Urbanek, R. S. Legro, D. Driscoll, J. F. Strauss, A. Dunaif, R. S. Spielman

Research output: Contribution to journalArticlepeer-review

38 Scopus citations


PCOS is a common disorder of unknown etiology. Studies of first-degree relatives of women diagnosed with PCOS suggest familial clustering of the disease. A prospective study of first-degree female relatives of women with PCOS conducted by NCPIR found that 46% of ascertainable sisters of women with PCOS were hyperandrogenemic. NCPIR has conducted linkage and association studies using affected sibling-pair analysis and the transmission/disequilibrium test to explore candidate PCOS genes. These studies point a finger at a region 1 MB centromeric to the insulin receptor gene on chromosome 19.

Original languageEnglish (US)
Pages (from-to)1311-1313
Number of pages3
JournalJournal of Pediatric Endocrinology and Metabolism
Issue numberSUPPL. 5
StatePublished - Dec 13 2000

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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