Seasonality of blood neopterin levels in the Old Order Amish

Hira Mohyuddin, Polymnia Georgiou, Abhishek Wadhawan, Melanie L. Daue, Lisa A. Brenner, Claudia Gragnoli, Erika F.H. Saunders, Dietmar Fuchs, Christopher A. Lowry, Teodor T. Postolache

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Seasonal changes in non-human animals and seasonal affective disorder (SAD) in humans are associated with immune activation in winter relative to summer. We intended to measure seasonal variation in neopterin, a marker of cellular immunity, its interactions with gender and seasonality of mood. We studied 320 Amish from Lancaster, PA, USA (men=128; 40%) with an average age [Standard deviation (SD)] of 56.7 (13.9) years. Blood neopterin level was measured with enzyme-linked immunosorbent assay (ELISA). Seasonality was measured with Seasonal Pattern Assessment Questionnaire (SPAQ). Statistical analysis included analysis of covariance (ANCOVAs) and multivariate linear regression. We also investigated interactions of seasonal differences in neopterin with gender, seasonality scores and estimation of SAD diagnosis. We found a significantly higher neopterin level in winter than in summer (p=0.006). There were no significant gender or seasonality interactions. Our study confirmed the hypothesized higher neopterin level in winter. A cross sectional design was our major limitation. If this finding will be replicated by longitudinal studies in multiple groups, neopterin could be used to monitor immune status across seasons in demographically diverse samples, even if heterogeneous in gender distribution, degree of seasonality of mood.

Original languageEnglish (US)
Pages (from-to)163-176
Number of pages14
JournalPteridines
Volume28
Issue number3-4
DOIs
StatePublished - Dec 20 2017

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Amish
Neopterin
Blood
Seasonal Affective Disorder
Immunosorbents
Linear regression
Cellular Immunity
Longitudinal Studies
Linear Models
Assays
Statistical methods
Animals
Multivariate Analysis
Chemical activation
Enzyme-Linked Immunosorbent Assay
Enzymes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Clinical Biochemistry

Cite this

Mohyuddin, H., Georgiou, P., Wadhawan, A., Daue, M. L., Brenner, L. A., Gragnoli, C., ... Postolache, T. T. (2017). Seasonality of blood neopterin levels in the Old Order Amish. Pteridines, 28(3-4), 163-176. https://doi.org/10.1515/pterid-2017-0020
Mohyuddin, Hira ; Georgiou, Polymnia ; Wadhawan, Abhishek ; Daue, Melanie L. ; Brenner, Lisa A. ; Gragnoli, Claudia ; Saunders, Erika F.H. ; Fuchs, Dietmar ; Lowry, Christopher A. ; Postolache, Teodor T. / Seasonality of blood neopterin levels in the Old Order Amish. In: Pteridines. 2017 ; Vol. 28, No. 3-4. pp. 163-176.
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Mohyuddin, H, Georgiou, P, Wadhawan, A, Daue, ML, Brenner, LA, Gragnoli, C, Saunders, EFH, Fuchs, D, Lowry, CA & Postolache, TT 2017, 'Seasonality of blood neopterin levels in the Old Order Amish', Pteridines, vol. 28, no. 3-4, pp. 163-176. https://doi.org/10.1515/pterid-2017-0020

Seasonality of blood neopterin levels in the Old Order Amish. / Mohyuddin, Hira; Georgiou, Polymnia; Wadhawan, Abhishek; Daue, Melanie L.; Brenner, Lisa A.; Gragnoli, Claudia; Saunders, Erika F.H.; Fuchs, Dietmar; Lowry, Christopher A.; Postolache, Teodor T.

In: Pteridines, Vol. 28, No. 3-4, 20.12.2017, p. 163-176.

Research output: Contribution to journalArticle

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AU - Georgiou, Polymnia

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AU - Saunders, Erika F.H.

AU - Fuchs, Dietmar

AU - Lowry, Christopher A.

AU - Postolache, Teodor T.

PY - 2017/12/20

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N2 - Seasonal changes in non-human animals and seasonal affective disorder (SAD) in humans are associated with immune activation in winter relative to summer. We intended to measure seasonal variation in neopterin, a marker of cellular immunity, its interactions with gender and seasonality of mood. We studied 320 Amish from Lancaster, PA, USA (men=128; 40%) with an average age [Standard deviation (SD)] of 56.7 (13.9) years. Blood neopterin level was measured with enzyme-linked immunosorbent assay (ELISA). Seasonality was measured with Seasonal Pattern Assessment Questionnaire (SPAQ). Statistical analysis included analysis of covariance (ANCOVAs) and multivariate linear regression. We also investigated interactions of seasonal differences in neopterin with gender, seasonality scores and estimation of SAD diagnosis. We found a significantly higher neopterin level in winter than in summer (p=0.006). There were no significant gender or seasonality interactions. Our study confirmed the hypothesized higher neopterin level in winter. A cross sectional design was our major limitation. If this finding will be replicated by longitudinal studies in multiple groups, neopterin could be used to monitor immune status across seasons in demographically diverse samples, even if heterogeneous in gender distribution, degree of seasonality of mood.

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Mohyuddin H, Georgiou P, Wadhawan A, Daue ML, Brenner LA, Gragnoli C et al. Seasonality of blood neopterin levels in the Old Order Amish. Pteridines. 2017 Dec 20;28(3-4):163-176. https://doi.org/10.1515/pterid-2017-0020