Seatbelts in CAR therapy: How safe are CARS?

Kentaro Minagawa, Xiaoou Zhou, Shin Mineishi, Antonio Di Stasi

Research output: Contribution to journalReview articlepeer-review

32 Scopus citations

Abstract

T-cells genetically redirected with a chimeric antigen receptor (CAR) to recognize tumor antigens and kill tumor cells have been infused in several phase 1 clinical trials with success. Due to safety concerns related to on-target/off-tumor effects or cytokine release syndrome, however, strategies to prevent or abate serious adverse events are required. Pharmacologic therapies; suicide genes; or novel strategies to limit the cytotoxic effect only to malignant cells are under active investigations. In this review, we summarize results and toxicities of investigations employing CAR redirected T-cells, with a focus on published strategies to grant safety of this promising cellular application.

Original languageEnglish (US)
Pages (from-to)230-249
Number of pages20
JournalPharmaceuticals
Volume8
Issue number2
DOIs
StatePublished - May 8 2015

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmaceutical Science

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