Secondary corneal amyloidosis after perforating corneal trauma: A series of 5 cases and review of the literature

Solin Saleh, Seymour Brownstein, Joshua S. Manusow, André Jastrzebski, Kay Lam, Joseph Sassani, George Mintsioulis, Steven M. Gilberg

Research output: Contribution to journalReview article

Abstract

We retrospectively reviewed the clinical and surgical histories of 5 patients with traumatic secondary corneal amyloidosis, a relatively rare sequela of nonsurgical and surgical perforating corneal trauma. Four had history of nonsurgical trauma, and 1 had surgical trauma to the cornea. Three specimens were obtained by penetrating keratoplasties and 2 by excision of the cornea during evisceration of the ocular contents. All the corneal specimens showed full-thickness scars of a prior perforating wound with congophilic amyloid deposits that exhibited apple-green birefringence under polarized light and dichroism. All cases had variable degrees of predominantly chronic nongranulomatous inflammation. Ultrastructural examination in 1 patient disclosed 8-nm diameter fibrils in disarray, consistent with amyloid. Amyloid P immunostaining was positive in all 3 patients tested for this protein.

Original languageEnglish (US)
Pages (from-to)590-595
Number of pages6
JournalSurvey of Ophthalmology
Volume60
Issue number6
DOIs
StatePublished - Jan 1 2015

Fingerprint

Amyloid
Cornea
Wounds and Injuries
Birefringence
Penetrating Keratoplasty
Amyloid Plaques
Cicatrix
Inflammation
Light
Corneal Injuries
Gelatinous drop-like corneal dystrophy
Proteins

All Science Journal Classification (ASJC) codes

  • Ophthalmology

Cite this

Saleh, Solin ; Brownstein, Seymour ; Manusow, Joshua S. ; Jastrzebski, André ; Lam, Kay ; Sassani, Joseph ; Mintsioulis, George ; Gilberg, Steven M. / Secondary corneal amyloidosis after perforating corneal trauma : A series of 5 cases and review of the literature. In: Survey of Ophthalmology. 2015 ; Vol. 60, No. 6. pp. 590-595.
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Saleh, S, Brownstein, S, Manusow, JS, Jastrzebski, A, Lam, K, Sassani, J, Mintsioulis, G & Gilberg, SM 2015, 'Secondary corneal amyloidosis after perforating corneal trauma: A series of 5 cases and review of the literature', Survey of Ophthalmology, vol. 60, no. 6, pp. 590-595. https://doi.org/10.1016/j.survophthal.2015.07.004

Secondary corneal amyloidosis after perforating corneal trauma : A series of 5 cases and review of the literature. / Saleh, Solin; Brownstein, Seymour; Manusow, Joshua S.; Jastrzebski, André; Lam, Kay; Sassani, Joseph; Mintsioulis, George; Gilberg, Steven M.

In: Survey of Ophthalmology, Vol. 60, No. 6, 01.01.2015, p. 590-595.

Research output: Contribution to journalReview article

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AU - Saleh, Solin

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