Secondary infections, expanded tissue tropism, and evidence for malignant potential in immunocompromised mice infected with Mus musculus papillomavirus 1 DNA and virus

Nancy M. Cladel, Lynn R. Budgeon, Timothy K. Cooper, Karla K. Balogh, Jiafen Hu, Neil D. Christensen

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

Papillomavirus disease poses a special challenge to people with compromised immune systems. Appropriate models to study infections in these individuals are lacking. We report here the development of a model that will help to address these deficiencies. The MmuPV1 genome was synthesized and used successfully to produce virus from DNA infections in immunocompromised mice. In these early studies, we have demonstrated both primary and secondary infections, expanded tissue tropism, and extensive dysplasia.

Original languageEnglish (US)
Pages (from-to)9391-9395
Number of pages5
JournalJournal of virology
Volume87
Issue number16
DOIs
StatePublished - Aug 1 2013

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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