Secondary infections, expanded tissue tropism, and evidence for malignant potential in immunocompromised mice infected with Mus musculus papillomavirus 1 DNA and virus

Nancy M. Cladel, Lynn R. Budgeon, Timothy K. Cooper, Karla K. Balogh, Jiafen Hu, Neil D. Christensen

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Papillomavirus disease poses a special challenge to people with compromised immune systems. Appropriate models to study infections in these individuals are lacking. We report here the development of a model that will help to address these deficiencies. The MmuPV1 genome was synthesized and used successfully to produce virus from DNA infections in immunocompromised mice. In these early studies, we have demonstrated both primary and secondary infections, expanded tissue tropism, and extensive dysplasia.

Original languageEnglish (US)
Pages (from-to)9391-9395
Number of pages5
JournalJournal of virology
Volume87
Issue number16
DOIs
StatePublished - Aug 1 2013

Fingerprint

DNA Virus Infections
tissue tropism
Tropism
DNA Viruses
Papillomaviridae
Mus musculus
Coinfection
Immune System
Genome
viruses
mice
DNA
Infection
infection
immune system
genome
secondary infection

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

Cite this

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Secondary infections, expanded tissue tropism, and evidence for malignant potential in immunocompromised mice infected with Mus musculus papillomavirus 1 DNA and virus. / Cladel, Nancy M.; Budgeon, Lynn R.; Cooper, Timothy K.; Balogh, Karla K.; Hu, Jiafen; Christensen, Neil D.

In: Journal of virology, Vol. 87, No. 16, 01.08.2013, p. 9391-9395.

Research output: Contribution to journalArticle

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