Abstract
HBV replicates its DNA genome, a partially double-stranded, relaxed circular DNA, via reverse transcription of an RNA intermediate called pre-genomic RNA by its reverse transcriptase. A major characteristic of HBV replication is the selective envelopment and secretion of relaxed circular DNA-containing mature capsids and empty capsids with no DNA or RNA, but not those containing pre-genomic RNA or the single-stranded DNA replication intermediate. In this review, the potential mechanisms of HBV virion morphogenesis will be discussed, with a focus on key determinants of both the capsid and envelope proteins for the selective secretion of complete and empty virions.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 95-105 |
| Number of pages | 11 |
| Journal | Future Virology |
| Volume | 14 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 1 2019 |
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All Science Journal Classification (ASJC) codes
- Virology
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Secretion of empty or complete hepatitis B virions : Envelopment of empty capsids versus mature nucleocapsids. / Liu, Kuancheng; Hu, Jianming.
In: Future Virology, Vol. 14, No. 2, 01.02.2019, p. 95-105.Research output: Contribution to journal › Review article
TY - JOUR
T1 - Secretion of empty or complete hepatitis B virions
T2 - Envelopment of empty capsids versus mature nucleocapsids
AU - Liu, Kuancheng
AU - Hu, Jianming
PY - 2019/2/1
Y1 - 2019/2/1
N2 - HBV replicates its DNA genome, a partially double-stranded, relaxed circular DNA, via reverse transcription of an RNA intermediate called pre-genomic RNA by its reverse transcriptase. A major characteristic of HBV replication is the selective envelopment and secretion of relaxed circular DNA-containing mature capsids and empty capsids with no DNA or RNA, but not those containing pre-genomic RNA or the single-stranded DNA replication intermediate. In this review, the potential mechanisms of HBV virion morphogenesis will be discussed, with a focus on key determinants of both the capsid and envelope proteins for the selective secretion of complete and empty virions.
AB - HBV replicates its DNA genome, a partially double-stranded, relaxed circular DNA, via reverse transcription of an RNA intermediate called pre-genomic RNA by its reverse transcriptase. A major characteristic of HBV replication is the selective envelopment and secretion of relaxed circular DNA-containing mature capsids and empty capsids with no DNA or RNA, but not those containing pre-genomic RNA or the single-stranded DNA replication intermediate. In this review, the potential mechanisms of HBV virion morphogenesis will be discussed, with a focus on key determinants of both the capsid and envelope proteins for the selective secretion of complete and empty virions.
UR - http://www.scopus.com/inward/record.url?scp=85061778232&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85061778232&partnerID=8YFLogxK
U2 - 10.2217/fvl-2018-0128
DO - 10.2217/fvl-2018-0128
M3 - Review article
AN - SCOPUS:85061778232
VL - 14
SP - 95
EP - 105
JO - Future Virology
JF - Future Virology
SN - 1746-0794
IS - 2
ER -