TY - JOUR
T1 - Secretion of empty or complete hepatitis B virions
T2 - Envelopment of empty capsids versus mature nucleocapsids
AU - Liu, Kuancheng
AU - Hu, Jianming
N1 - Funding Information:
Work in the authors’ laboratory has been supported by US Public Health Service grants to J Hu (AI043453, AI074982 and AI127670) from the National Institutes of Health and Zhejiang Provincial Natural Science Foundation for Young Scientist to K Liu (LQ19H190003). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.
PY - 2019/2
Y1 - 2019/2
N2 - HBV replicates its DNA genome, a partially double-stranded, relaxed circular DNA, via reverse transcription of an RNA intermediate called pre-genomic RNA by its reverse transcriptase. A major characteristic of HBV replication is the selective envelopment and secretion of relaxed circular DNA-containing mature capsids and empty capsids with no DNA or RNA, but not those containing pre-genomic RNA or the single-stranded DNA replication intermediate. In this review, the potential mechanisms of HBV virion morphogenesis will be discussed, with a focus on key determinants of both the capsid and envelope proteins for the selective secretion of complete and empty virions.
AB - HBV replicates its DNA genome, a partially double-stranded, relaxed circular DNA, via reverse transcription of an RNA intermediate called pre-genomic RNA by its reverse transcriptase. A major characteristic of HBV replication is the selective envelopment and secretion of relaxed circular DNA-containing mature capsids and empty capsids with no DNA or RNA, but not those containing pre-genomic RNA or the single-stranded DNA replication intermediate. In this review, the potential mechanisms of HBV virion morphogenesis will be discussed, with a focus on key determinants of both the capsid and envelope proteins for the selective secretion of complete and empty virions.
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U2 - 10.2217/fvl-2018-0128
DO - 10.2217/fvl-2018-0128
M3 - Review article
AN - SCOPUS:85061778232
VL - 14
SP - 95
EP - 105
JO - Future Virology
JF - Future Virology
SN - 1746-0794
IS - 2
ER -