Secretion of empty or complete hepatitis B virions: Envelopment of empty capsids versus mature nucleocapsids

Kuancheng Liu, Jianming Hu

Research output: Contribution to journalReview article

Abstract

HBV replicates its DNA genome, a partially double-stranded, relaxed circular DNA, via reverse transcription of an RNA intermediate called pre-genomic RNA by its reverse transcriptase. A major characteristic of HBV replication is the selective envelopment and secretion of relaxed circular DNA-containing mature capsids and empty capsids with no DNA or RNA, but not those containing pre-genomic RNA or the single-stranded DNA replication intermediate. In this review, the potential mechanisms of HBV virion morphogenesis will be discussed, with a focus on key determinants of both the capsid and envelope proteins for the selective secretion of complete and empty virions.

Original languageEnglish (US)
Pages (from-to)95-105
Number of pages11
JournalFuture Virology
Volume14
Issue number2
DOIs
StatePublished - Feb 1 2019

Fingerprint

Nucleocapsid
Capsid
Hepatitis B
Virion
RNA
Circular DNA
Single-Stranded DNA
RNA-Directed DNA Polymerase
DNA
Capsid Proteins
DNA Replication
Morphogenesis
Reverse Transcription
Genome

All Science Journal Classification (ASJC) codes

  • Virology

Cite this

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Secretion of empty or complete hepatitis B virions : Envelopment of empty capsids versus mature nucleocapsids. / Liu, Kuancheng; Hu, Jianming.

In: Future Virology, Vol. 14, No. 2, 01.02.2019, p. 95-105.

Research output: Contribution to journalReview article

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