Sedentary behavior is associated with impaired biomarkers in claudicants

Breno Q. Farah, Raphael M. Ritti-Dias, Polly S. Montgomery, Ana I. Casanegra, Federico Silva-Palacios, Andrew Gardner

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objective Time spent in sedentary behavior has been associated with worse inflammation and cardiometabolic biomarkers in various populations. However, the association between time spent in sedentary behavior and biomarkers remains unknown in patients with intermittent claudication. The aim of the current study was to analyze the relationship between sedentary behavior and inflammatory and cardiometabolic biomarkers in patients with symptomatic peripheral arterial disease (PAD). Methods The sample included 297 patients with intermittent claudication. Sedentary behavior was assessed using a step activity monitor. Biomarkers of inflammation, oxidative stress, lipid profile, insulin resistance, and endogenous fibrinolysis were assessed. Demographic data, body mass index, physical activity status, and measures of severity of PAD (ankle-brachial index, peak walking time, and ischemic window) also were obtained. Results Time spent in sedentary behavior was related with high-sensitivity C-reactive protein (b = 0.187; P =.005), glucose (b = 0.238; P <.001), fibrinogen (b = 0.167; P =.017), plasminogen activator inhibitor 1 activity (b = 0.143; P =.036), and high-density lipoprotein cholesterol (b = -0.133; P =.029). After adjustment for sex, age, physical activity status, body mass index, and severity of PAD, sedentary behavior remained related with high-sensitivity C-reactive protein (b = 0.170; P =.015), glucose (b = 0.178; P =.004), fibrinogen (b = 0.189; P =.010), and high-density lipoprotein cholesterol (b = -0.128; P =.032). Conclusions Time spent in sedentary activities was associated with worse inflammatory and cardiometabolic profile in patients with intermittent claudication.

Original languageEnglish (US)
Pages (from-to)657-663
Number of pages7
JournalJournal of Vascular Surgery
Volume63
Issue number3
DOIs
StatePublished - Mar 1 2016

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Biomarkers
Intermittent Claudication
Peripheral Arterial Disease
C-Reactive Protein
Fibrinogen
HDL Cholesterol
Body Mass Index
Exercise
Inflammation
Glucose
Ankle Brachial Index
Plasminogen Activator Inhibitor 1
Fibrinolysis
Walking
Insulin Resistance
Oxidative Stress
Demography
Lipids
Population

All Science Journal Classification (ASJC) codes

  • Surgery
  • Cardiology and Cardiovascular Medicine

Cite this

Farah, B. Q., Ritti-Dias, R. M., Montgomery, P. S., Casanegra, A. I., Silva-Palacios, F., & Gardner, A. (2016). Sedentary behavior is associated with impaired biomarkers in claudicants. Journal of Vascular Surgery, 63(3), 657-663. https://doi.org/10.1016/j.jvs.2015.09.018
Farah, Breno Q. ; Ritti-Dias, Raphael M. ; Montgomery, Polly S. ; Casanegra, Ana I. ; Silva-Palacios, Federico ; Gardner, Andrew. / Sedentary behavior is associated with impaired biomarkers in claudicants. In: Journal of Vascular Surgery. 2016 ; Vol. 63, No. 3. pp. 657-663.
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abstract = "Objective Time spent in sedentary behavior has been associated with worse inflammation and cardiometabolic biomarkers in various populations. However, the association between time spent in sedentary behavior and biomarkers remains unknown in patients with intermittent claudication. The aim of the current study was to analyze the relationship between sedentary behavior and inflammatory and cardiometabolic biomarkers in patients with symptomatic peripheral arterial disease (PAD). Methods The sample included 297 patients with intermittent claudication. Sedentary behavior was assessed using a step activity monitor. Biomarkers of inflammation, oxidative stress, lipid profile, insulin resistance, and endogenous fibrinolysis were assessed. Demographic data, body mass index, physical activity status, and measures of severity of PAD (ankle-brachial index, peak walking time, and ischemic window) also were obtained. Results Time spent in sedentary behavior was related with high-sensitivity C-reactive protein (b = 0.187; P =.005), glucose (b = 0.238; P <.001), fibrinogen (b = 0.167; P =.017), plasminogen activator inhibitor 1 activity (b = 0.143; P =.036), and high-density lipoprotein cholesterol (b = -0.133; P =.029). After adjustment for sex, age, physical activity status, body mass index, and severity of PAD, sedentary behavior remained related with high-sensitivity C-reactive protein (b = 0.170; P =.015), glucose (b = 0.178; P =.004), fibrinogen (b = 0.189; P =.010), and high-density lipoprotein cholesterol (b = -0.128; P =.032). Conclusions Time spent in sedentary activities was associated with worse inflammatory and cardiometabolic profile in patients with intermittent claudication.",
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Farah, BQ, Ritti-Dias, RM, Montgomery, PS, Casanegra, AI, Silva-Palacios, F & Gardner, A 2016, 'Sedentary behavior is associated with impaired biomarkers in claudicants', Journal of Vascular Surgery, vol. 63, no. 3, pp. 657-663. https://doi.org/10.1016/j.jvs.2015.09.018

Sedentary behavior is associated with impaired biomarkers in claudicants. / Farah, Breno Q.; Ritti-Dias, Raphael M.; Montgomery, Polly S.; Casanegra, Ana I.; Silva-Palacios, Federico; Gardner, Andrew.

In: Journal of Vascular Surgery, Vol. 63, No. 3, 01.03.2016, p. 657-663.

Research output: Contribution to journalArticle

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T1 - Sedentary behavior is associated with impaired biomarkers in claudicants

AU - Farah, Breno Q.

AU - Ritti-Dias, Raphael M.

AU - Montgomery, Polly S.

AU - Casanegra, Ana I.

AU - Silva-Palacios, Federico

AU - Gardner, Andrew

PY - 2016/3/1

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N2 - Objective Time spent in sedentary behavior has been associated with worse inflammation and cardiometabolic biomarkers in various populations. However, the association between time spent in sedentary behavior and biomarkers remains unknown in patients with intermittent claudication. The aim of the current study was to analyze the relationship between sedentary behavior and inflammatory and cardiometabolic biomarkers in patients with symptomatic peripheral arterial disease (PAD). Methods The sample included 297 patients with intermittent claudication. Sedentary behavior was assessed using a step activity monitor. Biomarkers of inflammation, oxidative stress, lipid profile, insulin resistance, and endogenous fibrinolysis were assessed. Demographic data, body mass index, physical activity status, and measures of severity of PAD (ankle-brachial index, peak walking time, and ischemic window) also were obtained. Results Time spent in sedentary behavior was related with high-sensitivity C-reactive protein (b = 0.187; P =.005), glucose (b = 0.238; P <.001), fibrinogen (b = 0.167; P =.017), plasminogen activator inhibitor 1 activity (b = 0.143; P =.036), and high-density lipoprotein cholesterol (b = -0.133; P =.029). After adjustment for sex, age, physical activity status, body mass index, and severity of PAD, sedentary behavior remained related with high-sensitivity C-reactive protein (b = 0.170; P =.015), glucose (b = 0.178; P =.004), fibrinogen (b = 0.189; P =.010), and high-density lipoprotein cholesterol (b = -0.128; P =.032). Conclusions Time spent in sedentary activities was associated with worse inflammatory and cardiometabolic profile in patients with intermittent claudication.

AB - Objective Time spent in sedentary behavior has been associated with worse inflammation and cardiometabolic biomarkers in various populations. However, the association between time spent in sedentary behavior and biomarkers remains unknown in patients with intermittent claudication. The aim of the current study was to analyze the relationship between sedentary behavior and inflammatory and cardiometabolic biomarkers in patients with symptomatic peripheral arterial disease (PAD). Methods The sample included 297 patients with intermittent claudication. Sedentary behavior was assessed using a step activity monitor. Biomarkers of inflammation, oxidative stress, lipid profile, insulin resistance, and endogenous fibrinolysis were assessed. Demographic data, body mass index, physical activity status, and measures of severity of PAD (ankle-brachial index, peak walking time, and ischemic window) also were obtained. Results Time spent in sedentary behavior was related with high-sensitivity C-reactive protein (b = 0.187; P =.005), glucose (b = 0.238; P <.001), fibrinogen (b = 0.167; P =.017), plasminogen activator inhibitor 1 activity (b = 0.143; P =.036), and high-density lipoprotein cholesterol (b = -0.133; P =.029). After adjustment for sex, age, physical activity status, body mass index, and severity of PAD, sedentary behavior remained related with high-sensitivity C-reactive protein (b = 0.170; P =.015), glucose (b = 0.178; P =.004), fibrinogen (b = 0.189; P =.010), and high-density lipoprotein cholesterol (b = -0.128; P =.032). Conclusions Time spent in sedentary activities was associated with worse inflammatory and cardiometabolic profile in patients with intermittent claudication.

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Farah BQ, Ritti-Dias RM, Montgomery PS, Casanegra AI, Silva-Palacios F, Gardner A. Sedentary behavior is associated with impaired biomarkers in claudicants. Journal of Vascular Surgery. 2016 Mar 1;63(3):657-663. https://doi.org/10.1016/j.jvs.2015.09.018