Segmental analysis of carotid arterial strain using speckle-tracking

Eric Y. Yang, Hisham Dokainish, Salim S. Virani, Arunima Misra, Allison M. Pritchett, Nasser Lakkis, Gerd Brunner, Jaromir Bobek, Marti L. McCulloch, Craig J. Hartley, Christie M. Ballantyne, Sherif F. Nagueh, Vijay Nambi

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Background: Increased arterial stiffness has been shown to be associated with aging and cardiovascular risk factors. Speckle-tracking algorithms are being used to measure myocardial strain. The aims of this study were to evaluate whether speckle-tracking could be used to measure carotid arterial strain (CAS) reproducibly in healthy volunteers and to determine if CAS was lesser in individuals with diabetes. Methods: Bilateral electrocardiographically gated ultrasound scans of the distal common carotid arteries (three cardiac cycles; 14-MHz linear probe; mean frame rate, 78.7 ± 8.9 frames/sec) were performed twice (2-4 days apart) on 10 healthy volunteers to test repeatability. Differences in CAS between healthy subjects (n = 20) and patients with diabetes (n = 21) were examined. Peak CAS was measured in each of six equal segments, and averages of all segments (i.e., the global average), of the three segments nearest the probe, and of the three segments farthest from the probe (i.e., the far wall average) were obtained. Results: Global CAS (intraclass correlation coefficient = 0.40) and far wall average (intraclass correlation coefficient = 0.63) had the greatest test-retest reliability. Global and far wall averaged CAS values were lower in patients with diabetes (4.29% [SE, 0.27%] and 4.30% [SE, 0.44%], respectively) than in controls (5.48% [SE, 0.29%], P =.001, and 5.58% [SE, 0.44%], P =.003, respectively). This difference persisted after adjustment for age, gender, race, and hemodynamic parameters. Conclusions: Speckle-tracking to measure CAS is feasible and modestly reliable. Patients with diabetes had lower CAS obtained with speckle-tracking compared with healthy controls.

Original languageEnglish (US)
Pages (from-to)1276-1284.e5
JournalJournal of the American Society of Echocardiography
Volume24
Issue number11
DOIs
StatePublished - Jan 1 2011

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Healthy Volunteers
Vascular Stiffness
Common Carotid Artery
Reproducibility of Results
Hemodynamics

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

Yang, E. Y., Dokainish, H., Virani, S. S., Misra, A., Pritchett, A. M., Lakkis, N., ... Nambi, V. (2011). Segmental analysis of carotid arterial strain using speckle-tracking. Journal of the American Society of Echocardiography, 24(11), 1276-1284.e5. https://doi.org/10.1016/j.echo.2011.08.002
Yang, Eric Y. ; Dokainish, Hisham ; Virani, Salim S. ; Misra, Arunima ; Pritchett, Allison M. ; Lakkis, Nasser ; Brunner, Gerd ; Bobek, Jaromir ; McCulloch, Marti L. ; Hartley, Craig J. ; Ballantyne, Christie M. ; Nagueh, Sherif F. ; Nambi, Vijay. / Segmental analysis of carotid arterial strain using speckle-tracking. In: Journal of the American Society of Echocardiography. 2011 ; Vol. 24, No. 11. pp. 1276-1284.e5.
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title = "Segmental analysis of carotid arterial strain using speckle-tracking",
abstract = "Background: Increased arterial stiffness has been shown to be associated with aging and cardiovascular risk factors. Speckle-tracking algorithms are being used to measure myocardial strain. The aims of this study were to evaluate whether speckle-tracking could be used to measure carotid arterial strain (CAS) reproducibly in healthy volunteers and to determine if CAS was lesser in individuals with diabetes. Methods: Bilateral electrocardiographically gated ultrasound scans of the distal common carotid arteries (three cardiac cycles; 14-MHz linear probe; mean frame rate, 78.7 ± 8.9 frames/sec) were performed twice (2-4 days apart) on 10 healthy volunteers to test repeatability. Differences in CAS between healthy subjects (n = 20) and patients with diabetes (n = 21) were examined. Peak CAS was measured in each of six equal segments, and averages of all segments (i.e., the global average), of the three segments nearest the probe, and of the three segments farthest from the probe (i.e., the far wall average) were obtained. Results: Global CAS (intraclass correlation coefficient = 0.40) and far wall average (intraclass correlation coefficient = 0.63) had the greatest test-retest reliability. Global and far wall averaged CAS values were lower in patients with diabetes (4.29{\%} [SE, 0.27{\%}] and 4.30{\%} [SE, 0.44{\%}], respectively) than in controls (5.48{\%} [SE, 0.29{\%}], P =.001, and 5.58{\%} [SE, 0.44{\%}], P =.003, respectively). This difference persisted after adjustment for age, gender, race, and hemodynamic parameters. Conclusions: Speckle-tracking to measure CAS is feasible and modestly reliable. Patients with diabetes had lower CAS obtained with speckle-tracking compared with healthy controls.",
author = "Yang, {Eric Y.} and Hisham Dokainish and Virani, {Salim S.} and Arunima Misra and Pritchett, {Allison M.} and Nasser Lakkis and Gerd Brunner and Jaromir Bobek and McCulloch, {Marti L.} and Hartley, {Craig J.} and Ballantyne, {Christie M.} and Nagueh, {Sherif F.} and Vijay Nambi",
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Yang, EY, Dokainish, H, Virani, SS, Misra, A, Pritchett, AM, Lakkis, N, Brunner, G, Bobek, J, McCulloch, ML, Hartley, CJ, Ballantyne, CM, Nagueh, SF & Nambi, V 2011, 'Segmental analysis of carotid arterial strain using speckle-tracking', Journal of the American Society of Echocardiography, vol. 24, no. 11, pp. 1276-1284.e5. https://doi.org/10.1016/j.echo.2011.08.002

Segmental analysis of carotid arterial strain using speckle-tracking. / Yang, Eric Y.; Dokainish, Hisham; Virani, Salim S.; Misra, Arunima; Pritchett, Allison M.; Lakkis, Nasser; Brunner, Gerd; Bobek, Jaromir; McCulloch, Marti L.; Hartley, Craig J.; Ballantyne, Christie M.; Nagueh, Sherif F.; Nambi, Vijay.

In: Journal of the American Society of Echocardiography, Vol. 24, No. 11, 01.01.2011, p. 1276-1284.e5.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Segmental analysis of carotid arterial strain using speckle-tracking

AU - Yang, Eric Y.

AU - Dokainish, Hisham

AU - Virani, Salim S.

AU - Misra, Arunima

AU - Pritchett, Allison M.

AU - Lakkis, Nasser

AU - Brunner, Gerd

AU - Bobek, Jaromir

AU - McCulloch, Marti L.

AU - Hartley, Craig J.

AU - Ballantyne, Christie M.

AU - Nagueh, Sherif F.

AU - Nambi, Vijay

PY - 2011/1/1

Y1 - 2011/1/1

N2 - Background: Increased arterial stiffness has been shown to be associated with aging and cardiovascular risk factors. Speckle-tracking algorithms are being used to measure myocardial strain. The aims of this study were to evaluate whether speckle-tracking could be used to measure carotid arterial strain (CAS) reproducibly in healthy volunteers and to determine if CAS was lesser in individuals with diabetes. Methods: Bilateral electrocardiographically gated ultrasound scans of the distal common carotid arteries (three cardiac cycles; 14-MHz linear probe; mean frame rate, 78.7 ± 8.9 frames/sec) were performed twice (2-4 days apart) on 10 healthy volunteers to test repeatability. Differences in CAS between healthy subjects (n = 20) and patients with diabetes (n = 21) were examined. Peak CAS was measured in each of six equal segments, and averages of all segments (i.e., the global average), of the three segments nearest the probe, and of the three segments farthest from the probe (i.e., the far wall average) were obtained. Results: Global CAS (intraclass correlation coefficient = 0.40) and far wall average (intraclass correlation coefficient = 0.63) had the greatest test-retest reliability. Global and far wall averaged CAS values were lower in patients with diabetes (4.29% [SE, 0.27%] and 4.30% [SE, 0.44%], respectively) than in controls (5.48% [SE, 0.29%], P =.001, and 5.58% [SE, 0.44%], P =.003, respectively). This difference persisted after adjustment for age, gender, race, and hemodynamic parameters. Conclusions: Speckle-tracking to measure CAS is feasible and modestly reliable. Patients with diabetes had lower CAS obtained with speckle-tracking compared with healthy controls.

AB - Background: Increased arterial stiffness has been shown to be associated with aging and cardiovascular risk factors. Speckle-tracking algorithms are being used to measure myocardial strain. The aims of this study were to evaluate whether speckle-tracking could be used to measure carotid arterial strain (CAS) reproducibly in healthy volunteers and to determine if CAS was lesser in individuals with diabetes. Methods: Bilateral electrocardiographically gated ultrasound scans of the distal common carotid arteries (three cardiac cycles; 14-MHz linear probe; mean frame rate, 78.7 ± 8.9 frames/sec) were performed twice (2-4 days apart) on 10 healthy volunteers to test repeatability. Differences in CAS between healthy subjects (n = 20) and patients with diabetes (n = 21) were examined. Peak CAS was measured in each of six equal segments, and averages of all segments (i.e., the global average), of the three segments nearest the probe, and of the three segments farthest from the probe (i.e., the far wall average) were obtained. Results: Global CAS (intraclass correlation coefficient = 0.40) and far wall average (intraclass correlation coefficient = 0.63) had the greatest test-retest reliability. Global and far wall averaged CAS values were lower in patients with diabetes (4.29% [SE, 0.27%] and 4.30% [SE, 0.44%], respectively) than in controls (5.48% [SE, 0.29%], P =.001, and 5.58% [SE, 0.44%], P =.003, respectively). This difference persisted after adjustment for age, gender, race, and hemodynamic parameters. Conclusions: Speckle-tracking to measure CAS is feasible and modestly reliable. Patients with diabetes had lower CAS obtained with speckle-tracking compared with healthy controls.

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Yang EY, Dokainish H, Virani SS, Misra A, Pritchett AM, Lakkis N et al. Segmental analysis of carotid arterial strain using speckle-tracking. Journal of the American Society of Echocardiography. 2011 Jan 1;24(11):1276-1284.e5. https://doi.org/10.1016/j.echo.2011.08.002