Seizure control following tumor surgery for childhood cortical low-grade gliomas

R. J. Packer, L. N. Sutton, K. M. Patel, A. C. Duhaime, S. Schiff, S. R. Weinstein, W. D. Gaillard, J. A. Conry, L. Schut

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Abstract

Detailed preoperative electroencephalographic (EEG) studies are now recommended for children with seizures and cortical tumors to define seizure foci prior to surgery. To develop a historical perspective for better evaluation of results from series reporting tumor removal combined with resection of seizure foci, the authors reviewed seizure outcome in 60 children with seizures and low-grade neoplasms treated consecutively since 1981 by surgical resection without concomitant EEG monitoring or electrocortical mapping. Forty-seven of the 60 tumors were totally or near- totally resected; 45 patients were seizure-free and two were significantly improved 1 year following surgery. Of the 50 children in this series with more than five seizures prior to surgery, 36 were seizure-free, two were significantly improved, and 12 were not improved. Factors associated with poor seizure control included a parietal tumor location, a partial tumor resection, and a history of seizures for more than 1 year prior to surgery. The children at highest risk for poor seizure control at 2 years had experienced seizures for more than 1 year prior to surgery and had undergone partial resection of their parietal low-grade glial tumors or gangliogliomas. In contradistinction, the best seizure control was seen in patients with totally resected low-grade gliomas or gangliogliomas who had experienced seizures for less than 1 year (concordance rates for being seizure-free ranged from 78% to 86%). Long-term seizure control remained excellent. These results suggest that seizure control can be obtained 2 years following tumor surgery in the majority of children with presumed tumors after extensive tumor resection without concomitant EEG monitoring or electrocortical mapping.

Original languageEnglish (US)
Pages (from-to)998-1003
Number of pages6
JournalJournal of neurosurgery
Volume80
Issue number6
DOIs
StatePublished - Jan 1 1994

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All Science Journal Classification (ASJC) codes

  • Surgery
  • Clinical Neurology

Cite this

Packer, R. J., Sutton, L. N., Patel, K. M., Duhaime, A. C., Schiff, S., Weinstein, S. R., Gaillard, W. D., Conry, J. A., & Schut, L. (1994). Seizure control following tumor surgery for childhood cortical low-grade gliomas. Journal of neurosurgery, 80(6), 998-1003. https://doi.org/10.3171/jns.1994.80.6.0998