Seizure modulation with applied electric fields in chronically implanted animals

S. Sunderam, N. Chernyy, J. Mason, N. Peixoto, S. L. Weinstein, S. J. Schiff, B. J. Gluckman

Research output: Chapter in Book/Report/Conference proceedingConference contribution

11 Citations (Scopus)

Abstract

Low Frequency (≪100Hz) applied electric fields have been shown to modulate neuronal activity both In Vitro and in acute whole animal studies [1-3], We have been working to apply this technology for seizure control in chronically implanted animals. We have developed electronics for simultaneously recording neural activity while stimulating with low frequency fields. We have observed transient entrainment of spike and wave activity during spontaneous seizures with open loop sinusoidal stimulation with frequencies between 9-15 Hz. This is the first demonstration of low frequency field modulation of neural activity in chronically implanted mammalian brain.

Original languageEnglish (US)
Title of host publication28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06
Pages1612-1615
Number of pages4
DOIs
StatePublished - Dec 1 2006
Event28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06 - New York, NY, United States
Duration: Aug 30 2006Sep 3 2006

Publication series

NameAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
ISSN (Print)0589-1019

Other

Other28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06
CountryUnited States
CityNew York, NY
Period8/30/069/3/06

Fingerprint

Animals
Seizures
Electric fields
Modulation
Brain
Electronic equipment
Demonstrations
Technology
In Vitro Techniques

All Science Journal Classification (ASJC) codes

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

Cite this

Sunderam, S., Chernyy, N., Mason, J., Peixoto, N., Weinstein, S. L., Schiff, S. J., & Gluckman, B. J. (2006). Seizure modulation with applied electric fields in chronically implanted animals. In 28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06 (pp. 1612-1615). [4030501] (Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings). https://doi.org/10.1109/IEMBS.2006.259454
Sunderam, S. ; Chernyy, N. ; Mason, J. ; Peixoto, N. ; Weinstein, S. L. ; Schiff, S. J. ; Gluckman, B. J. / Seizure modulation with applied electric fields in chronically implanted animals. 28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06. 2006. pp. 1612-1615 (Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings).
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Sunderam, S, Chernyy, N, Mason, J, Peixoto, N, Weinstein, SL, Schiff, SJ & Gluckman, BJ 2006, Seizure modulation with applied electric fields in chronically implanted animals. in 28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06., 4030501, Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, pp. 1612-1615, 28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06, New York, NY, United States, 8/30/06. https://doi.org/10.1109/IEMBS.2006.259454

Seizure modulation with applied electric fields in chronically implanted animals. / Sunderam, S.; Chernyy, N.; Mason, J.; Peixoto, N.; Weinstein, S. L.; Schiff, S. J.; Gluckman, B. J.

28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06. 2006. p. 1612-1615 4030501 (Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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Sunderam S, Chernyy N, Mason J, Peixoto N, Weinstein SL, Schiff SJ et al. Seizure modulation with applied electric fields in chronically implanted animals. In 28th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'06. 2006. p. 1612-1615. 4030501. (Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings). https://doi.org/10.1109/IEMBS.2006.259454