Seizure Suppression in a Thalamocortical Computational Model of Absence Epilepsy by Linear Delayed Feedback Control

Bo Zhou, Yanqiu Che, Qing Qin, Yingmei Qin, Chunxiao Han

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Using a thalamocortical computational model of absence epilepsy, we consider the linear delayed feedback control (LDFC) as a brain stimulation strategy for seizure suppression. The model consists of a pyramidal cell population (PY) and an interneuron population (IN) in the cortex and thalamocortical relay cells (TC) and reticular nucleus (RE) in the thalamus. Without control, the system behaves spike-and-wave discharges (SWDs). The typical LDFC with a constant feedback gain and a constant time delay, can effectively suppressed seizures only in a certain range of the parameter space. We propose to use a periodic time delay instead. The seizure can be effectively suppressed in almost the full parameter space. The underlying control mechanisms are also demonstrated. We recommend the LDFC with periodic time delays as a potential deep brain stimulation (DBS) therapy for absence epilepsy.

Original languageEnglish (US)
Title of host publicationProceedings - 2020 13th International Congress on Image and Signal Processing, BioMedical Engineering and Informatics, CISP-BMEI 2020
EditorsQiang Zheng, Xiaopeng Zheng, Xiangfu Zhao, Weiqing Yan, Nan Zhang, Lipo Wang
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages872-876
Number of pages5
ISBN (Electronic)9780738105451
DOIs
StatePublished - Oct 17 2020
Event13th International Congress on Image and Signal Processing, BioMedical Engineering and Informatics, CISP-BMEI 2020 - Virtual, Chengdu, China
Duration: Oct 17 2020Oct 19 2020

Publication series

NameProceedings - 2020 13th International Congress on Image and Signal Processing, BioMedical Engineering and Informatics, CISP-BMEI 2020

Conference

Conference13th International Congress on Image and Signal Processing, BioMedical Engineering and Informatics, CISP-BMEI 2020
CountryChina
CityVirtual, Chengdu
Period10/17/2010/19/20

All Science Journal Classification (ASJC) codes

  • Computer Vision and Pattern Recognition
  • Information Systems
  • Signal Processing
  • Biomedical Engineering
  • Health Informatics

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