@inproceedings{ce27cd0513434e5fb476fc460cd56c7d,
title = "Seizure Suppression in a Thalamocortical Computational Model of Absence Epilepsy by Linear Delayed Feedback Control",
abstract = "Using a thalamocortical computational model of absence epilepsy, we consider the linear delayed feedback control (LDFC) as a brain stimulation strategy for seizure suppression. The model consists of a pyramidal cell population (PY) and an interneuron population (IN) in the cortex and thalamocortical relay cells (TC) and reticular nucleus (RE) in the thalamus. Without control, the system behaves spike-and-wave discharges (SWDs). The typical LDFC with a constant feedback gain and a constant time delay, can effectively suppressed seizures only in a certain range of the parameter space. We propose to use a periodic time delay instead. The seizure can be effectively suppressed in almost the full parameter space. The underlying control mechanisms are also demonstrated. We recommend the LDFC with periodic time delays as a potential deep brain stimulation (DBS) therapy for absence epilepsy.",
author = "Bo Zhou and Yanqiu Che and Qing Qin and Yingmei Qin and Chunxiao Han",
note = "Funding Information: This work is supported by the Natural Science Foundation of Tianjin, China (Grant Nos. 18JCYBJC88200), National Natural Science Foundation of China (Grant No. 61801328) and Tianjin Municipal Special Program of Talent Development for Excellent Youth Scholars (Grant No. TJTZJH-QNBJRC-2-21). Publisher Copyright: {\textcopyright} 2020 IEEE.; 13th International Congress on Image and Signal Processing, BioMedical Engineering and Informatics, CISP-BMEI 2020 ; Conference date: 17-10-2020 Through 19-10-2020",
year = "2020",
month = oct,
day = "17",
doi = "10.1109/CISP-BMEI51763.2020.9263605",
language = "English (US)",
series = "Proceedings - 2020 13th International Congress on Image and Signal Processing, BioMedical Engineering and Informatics, CISP-BMEI 2020",
publisher = "Institute of Electrical and Electronics Engineers Inc.",
pages = "872--876",
editor = "Qiang Zheng and Xiaopeng Zheng and Xiangfu Zhao and Weiqing Yan and Nan Zhang and Lipo Wang",
booktitle = "Proceedings - 2020 13th International Congress on Image and Signal Processing, BioMedical Engineering and Informatics, CISP-BMEI 2020",
address = "United States",
}