TY - JOUR
T1 - Seizures associated with levofloxacin
T2 - Case presentation and literature review
AU - Bellon, Alfredo
AU - Perez-Garcia, Gonzalo
AU - Coverdale, John H.
AU - Chacko, Ranjit C.
N1 - Funding Information:
Acknowledgements AB receives financial support from the Fondation de la Recherche Medicale, France, CONACYT scholarship #74641 and the Young Minds in Psychiatry Award given by the American Psychiatric Association.
PY - 2009/10
Y1 - 2009/10
N2 - Purpose: We present a case of a patient who developed seizures shortly after initiating treatment with levofloxacin and to discuss the potential drug-drug interactions related to the inhibition of cytochrome P450 (CYP) 1A2 in this case, as well as in other cases, of levofloxacin-induced seizures. Methods: Several biomedical databases were searched including MEDLINE, Cochrane and Ovid. The main search terms utilized were case report and levofloxacin. The search was limited to studies published in English. Results: Six cases of levofloxacin-induced seizures have been reported in the literature. Drug-drug interactions related to the inhibition of CYP1A2 by levofloxacin are likely involved in the clinical outcome of these cases. Conclusions: Clinicians are exhorted to pay close attention when initiating levofloxacin therapy in patients taking medications with epileptogenic properties that are CYP1A2 substrates.
AB - Purpose: We present a case of a patient who developed seizures shortly after initiating treatment with levofloxacin and to discuss the potential drug-drug interactions related to the inhibition of cytochrome P450 (CYP) 1A2 in this case, as well as in other cases, of levofloxacin-induced seizures. Methods: Several biomedical databases were searched including MEDLINE, Cochrane and Ovid. The main search terms utilized were case report and levofloxacin. The search was limited to studies published in English. Results: Six cases of levofloxacin-induced seizures have been reported in the literature. Drug-drug interactions related to the inhibition of CYP1A2 by levofloxacin are likely involved in the clinical outcome of these cases. Conclusions: Clinicians are exhorted to pay close attention when initiating levofloxacin therapy in patients taking medications with epileptogenic properties that are CYP1A2 substrates.
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U2 - 10.1007/s00228-009-0717-5
DO - 10.1007/s00228-009-0717-5
M3 - Review article
C2 - 19707748
AN - SCOPUS:70349230758
VL - 65
SP - 959
EP - 962
JO - European Journal of Clinical Pharmacology
JF - European Journal of Clinical Pharmacology
SN - 0031-6970
IS - 10
ER -