Selecting genes by test statistics

Dechang Chen, Zhenqiu Liu, Xiaobin Ma, Dong Hua

Research output: Contribution to journalArticle

47 Scopus citations

Abstract

Gene selection is an important issue in analyzing multiclass microarray data. Among many proposed selection methods, the traditional ANOVA F test statistic has been employed to identify informative genes for both class prediction (classification) and discovery problems. However, the F test statistic assumes an equal variance. This assumption may not be realistic for gene expression data. This paper explores other alternative test statistics which can handle heterogeneity of the variances. We study five such test statistics, which include Brown-Forsythe test statistic and Welch test statistic. Their performance is evaluated and compared with that of F statistic over different classification methods applied to publicly available microarray datasets.

Original languageEnglish (US)
Pages (from-to)132-138
Number of pages7
JournalJournal of Biomedicine and Biotechnology
Volume2005
Issue number2
DOIs
StatePublished - Jun 30 2005

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Health, Toxicology and Mutagenesis

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