Selective Sweeps

Z. A. Szpiech, R. D. Hernandez

Research output: Chapter in Book/Report/Conference proceedingChapter


The model of a de novo adaptive mutation arising in a population and rising to high frequency is referred to as a selective sweep and has been the subject of much theoretical study. Here we describe the basic model, the expected genetic patterns that result from such a process, and two major classes of statistics designed to infer genomic locations that have recently experienced a selective sweep (those based on the site frequency spectrum and those based on haplotype patterns). We conclude by discussing caveats to the model and possible alternatives that are gaining traction in the field.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Evolutionary Biology
PublisherElsevier Inc.
Number of pages10
ISBN (Electronic)9780128004265
ISBN (Print)9780128000496
StatePublished - Apr 14 2016

All Science Journal Classification (ASJC) codes

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)


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