Selectivity of Thy-1 monoclonal antibodies in enhancing neurite outgrowth

Stuart A. Lipton, Dana Leifer, Colin Barnstable

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Thy-1 monoclonal antibodies (MAbs) have previously been shown to promote neurite outgrowth from retinal ganglion cells and a variety of other neurons. We have studied the effect on neurite outgrowth of several Thy-1 MAbs with quantitatively similar binding properties and found that only certain Thy-1 MAbs promote neurite outgrowth. This finding suggests that the antibody effects depend on specific interactions with one or more active sites on the Thy-1 glycoprotein.

Original languageEnglish (US)
Pages (from-to)75-77
Number of pages3
JournalNeuroscience letters
Volume137
Issue number1
DOIs
StatePublished - Mar 16 1992

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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