Selectivity of Thy-1 monoclonal antibodies in enhancing neurite outgrowth

Stuart A. Lipton, Dana Leifer, Colin Barnstable

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Thy-1 monoclonal antibodies (MAbs) have previously been shown to promote neurite outgrowth from retinal ganglion cells and a variety of other neurons. We have studied the effect on neurite outgrowth of several Thy-1 MAbs with quantitatively similar binding properties and found that only certain Thy-1 MAbs promote neurite outgrowth. This finding suggests that the antibody effects depend on specific interactions with one or more active sites on the Thy-1 glycoprotein.

Original languageEnglish (US)
Pages (from-to)75-77
Number of pages3
JournalNeuroscience letters
Volume137
Issue number1
DOIs
StatePublished - Mar 16 1992

Fingerprint

Monoclonal Antibodies
Retinal Ganglion Cells
Catalytic Domain
Glycoproteins
Neurons
Antibodies
Neuronal Outgrowth

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Lipton, Stuart A. ; Leifer, Dana ; Barnstable, Colin. / Selectivity of Thy-1 monoclonal antibodies in enhancing neurite outgrowth. In: Neuroscience letters. 1992 ; Vol. 137, No. 1. pp. 75-77.
@article{c078eed10f334ce19e7ccfb066b487cb,
title = "Selectivity of Thy-1 monoclonal antibodies in enhancing neurite outgrowth",
abstract = "Thy-1 monoclonal antibodies (MAbs) have previously been shown to promote neurite outgrowth from retinal ganglion cells and a variety of other neurons. We have studied the effect on neurite outgrowth of several Thy-1 MAbs with quantitatively similar binding properties and found that only certain Thy-1 MAbs promote neurite outgrowth. This finding suggests that the antibody effects depend on specific interactions with one or more active sites on the Thy-1 glycoprotein.",
author = "Lipton, {Stuart A.} and Dana Leifer and Colin Barnstable",
year = "1992",
month = "3",
day = "16",
doi = "10.1016/0304-3940(92)90302-N",
language = "English (US)",
volume = "137",
pages = "75--77",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
number = "1",

}

Selectivity of Thy-1 monoclonal antibodies in enhancing neurite outgrowth. / Lipton, Stuart A.; Leifer, Dana; Barnstable, Colin.

In: Neuroscience letters, Vol. 137, No. 1, 16.03.1992, p. 75-77.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Selectivity of Thy-1 monoclonal antibodies in enhancing neurite outgrowth

AU - Lipton, Stuart A.

AU - Leifer, Dana

AU - Barnstable, Colin

PY - 1992/3/16

Y1 - 1992/3/16

N2 - Thy-1 monoclonal antibodies (MAbs) have previously been shown to promote neurite outgrowth from retinal ganglion cells and a variety of other neurons. We have studied the effect on neurite outgrowth of several Thy-1 MAbs with quantitatively similar binding properties and found that only certain Thy-1 MAbs promote neurite outgrowth. This finding suggests that the antibody effects depend on specific interactions with one or more active sites on the Thy-1 glycoprotein.

AB - Thy-1 monoclonal antibodies (MAbs) have previously been shown to promote neurite outgrowth from retinal ganglion cells and a variety of other neurons. We have studied the effect on neurite outgrowth of several Thy-1 MAbs with quantitatively similar binding properties and found that only certain Thy-1 MAbs promote neurite outgrowth. This finding suggests that the antibody effects depend on specific interactions with one or more active sites on the Thy-1 glycoprotein.

UR - http://www.scopus.com/inward/record.url?scp=0026561642&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026561642&partnerID=8YFLogxK

U2 - 10.1016/0304-3940(92)90302-N

DO - 10.1016/0304-3940(92)90302-N

M3 - Article

C2 - 1352632

AN - SCOPUS:0026561642

VL - 137

SP - 75

EP - 77

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 1

ER -