Selenium and selenoproteins in gut inflammation—A review

Shaneice K. Nettleford, Kumble Sandeep Prabhu

Research output: Contribution to journalReview article

11 Citations (Scopus)

Abstract

Inflammatory bowel disease (IBD), characterized by severe flares and remissions, is a debilitating condition. While the etiology is unknown, many immune cells, such as macrophages, T cells and innate lymphoid cells, are implicated in the pathogenesis of the disease. Previous studies have shown the ability of micronutrient selenium (Se) and selenoproteins to impact inflammatory signaling pathways implicated in the pathogenesis of the disease. In particular, two transcription factors, nuclear factor-κB (NF-κB), and peroxisome proliferator activated receptor (PPAR)γ, which are involved in the activation of immune cells, and are also implicated in various stages of inflammation and resolution, respectively, are impacted by Se status. Available therapies for IBD produce detrimental side effects, resulting in the need for alternative therapies. Here, we review the current understanding of the role of NF-κB and PPARγ in the activation of immune cells during IBD, and how Se and selenoproteins modulate effective resolution of inflammation to be considered as a promising alternative to treat IBD.

Original languageEnglish (US)
Article number36
JournalAntioxidants
Volume7
Issue number3
DOIs
StatePublished - Mar 1 2018

Fingerprint

Selenoproteins
Selenium
Inflammatory Bowel Diseases
Peroxisome Proliferator-Activated Receptors
Inflammation
Micronutrients
Complementary Therapies
Chemical activation
Transcription Factors
T-cells
Macrophages
Lymphocytes
T-Lymphocytes

All Science Journal Classification (ASJC) codes

  • Physiology
  • Biochemistry
  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology

Cite this

@article{2d16e8d7e0724e6399a0867ce63b2042,
title = "Selenium and selenoproteins in gut inflammation—A review",
abstract = "Inflammatory bowel disease (IBD), characterized by severe flares and remissions, is a debilitating condition. While the etiology is unknown, many immune cells, such as macrophages, T cells and innate lymphoid cells, are implicated in the pathogenesis of the disease. Previous studies have shown the ability of micronutrient selenium (Se) and selenoproteins to impact inflammatory signaling pathways implicated in the pathogenesis of the disease. In particular, two transcription factors, nuclear factor-κB (NF-κB), and peroxisome proliferator activated receptor (PPAR)γ, which are involved in the activation of immune cells, and are also implicated in various stages of inflammation and resolution, respectively, are impacted by Se status. Available therapies for IBD produce detrimental side effects, resulting in the need for alternative therapies. Here, we review the current understanding of the role of NF-κB and PPARγ in the activation of immune cells during IBD, and how Se and selenoproteins modulate effective resolution of inflammation to be considered as a promising alternative to treat IBD.",
author = "Nettleford, {Shaneice K.} and Prabhu, {Kumble Sandeep}",
year = "2018",
month = "3",
day = "1",
doi = "10.3390/antiox7030036",
language = "English (US)",
volume = "7",
journal = "Antioxidants",
issn = "2076-3921",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "3",

}

Selenium and selenoproteins in gut inflammation—A review. / Nettleford, Shaneice K.; Prabhu, Kumble Sandeep.

In: Antioxidants, Vol. 7, No. 3, 36, 01.03.2018.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Selenium and selenoproteins in gut inflammation—A review

AU - Nettleford, Shaneice K.

AU - Prabhu, Kumble Sandeep

PY - 2018/3/1

Y1 - 2018/3/1

N2 - Inflammatory bowel disease (IBD), characterized by severe flares and remissions, is a debilitating condition. While the etiology is unknown, many immune cells, such as macrophages, T cells and innate lymphoid cells, are implicated in the pathogenesis of the disease. Previous studies have shown the ability of micronutrient selenium (Se) and selenoproteins to impact inflammatory signaling pathways implicated in the pathogenesis of the disease. In particular, two transcription factors, nuclear factor-κB (NF-κB), and peroxisome proliferator activated receptor (PPAR)γ, which are involved in the activation of immune cells, and are also implicated in various stages of inflammation and resolution, respectively, are impacted by Se status. Available therapies for IBD produce detrimental side effects, resulting in the need for alternative therapies. Here, we review the current understanding of the role of NF-κB and PPARγ in the activation of immune cells during IBD, and how Se and selenoproteins modulate effective resolution of inflammation to be considered as a promising alternative to treat IBD.

AB - Inflammatory bowel disease (IBD), characterized by severe flares and remissions, is a debilitating condition. While the etiology is unknown, many immune cells, such as macrophages, T cells and innate lymphoid cells, are implicated in the pathogenesis of the disease. Previous studies have shown the ability of micronutrient selenium (Se) and selenoproteins to impact inflammatory signaling pathways implicated in the pathogenesis of the disease. In particular, two transcription factors, nuclear factor-κB (NF-κB), and peroxisome proliferator activated receptor (PPAR)γ, which are involved in the activation of immune cells, and are also implicated in various stages of inflammation and resolution, respectively, are impacted by Se status. Available therapies for IBD produce detrimental side effects, resulting in the need for alternative therapies. Here, we review the current understanding of the role of NF-κB and PPARγ in the activation of immune cells during IBD, and how Se and selenoproteins modulate effective resolution of inflammation to be considered as a promising alternative to treat IBD.

UR - http://www.scopus.com/inward/record.url?scp=85042845930&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85042845930&partnerID=8YFLogxK

U2 - 10.3390/antiox7030036

DO - 10.3390/antiox7030036

M3 - Review article

C2 - 29494512

AN - SCOPUS:85042845930

VL - 7

JO - Antioxidants

JF - Antioxidants

SN - 2076-3921

IS - 3

M1 - 36

ER -