Selenium as a cancer preventive agent

Gerald F. Combs, Junxuan Lü

Research output: Chapter in Book/Report/Conference proceedingChapter

15 Citations (Scopus)

Abstract

Most epidemiological studies have shown inverse associations of selenium (Se) status and cancer risk; almost all experimental animal studies have shown that supranutritional exposures of Se can reduce tumor yield; and each of the limited number of clinical intervention trials conducted to date has found Se treatment to be associated with reductions in cancer risks. The known metabolic functions of Se, which appear to be discharged by a fairly small number of selenoproteins may not fully explain these effects, particularly those observed in response to Se-supplementation of non-deficient subjects. Emerging evidence indicates anticarcinogenic roles of at least some selenoproteins, namely, those involved in antioxidant protection (the glutathione peroxidases), redox regulation (the thioredoxin reductases) and hormonal regulation of metabolism (iodothyronine 5'-deiodinases). The fact that abundant empirical evidence has shown anti-carcinogenic effects of Se in individuals with apparently full selenoenzyme expression suggests other mechanisms with relevance to non-deficient populations. Certain Se-metabolites (hydrogen selenide, methylselenol, seleno-diglutathione) can be anti-carcinogenic by inhibiting cell proliferation, stimulating cell death by apoptosis, and inhibiting neoangiogenesis. Therefore, while the hypothesis remains plausible that Se-deprivation may increase cancer risk by compromising selenoprotein expression, there is strong support for the hypothesis that supranutritional exposures to Se can reduce cancer risk. These hypotheses are not mutually exclusive, and it is likely that Se can function as a cancer preventive agent through both nutritional and supranutritional mechanisms.

Original languageEnglish (US)
Title of host publicationSelenium
Subtitle of host publicationIts Molecular Biology and Role in Human Health, Second Edition
PublisherSpringer US
Pages249-264
Number of pages16
ISBN (Electronic)9780387338279
ISBN (Print)0387338268, 9780387338262
DOIs
StatePublished - Jan 1 2006

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Selenium
Selenoproteins
Neoplasms
Anticarcinogenic Agents
Thioredoxin-Disulfide Reductase
Iodide Peroxidase
Glutathione Peroxidase
Oxidation-Reduction
Epidemiologic Studies
Cell Death
Antioxidants
Cell Proliferation
Clinical Trials
Apoptosis

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Combs, G. F., & Lü, J. (2006). Selenium as a cancer preventive agent. In Selenium: Its Molecular Biology and Role in Human Health, Second Edition (pp. 249-264). Springer US. https://doi.org/10.1007/0-387-33827-6_22
Combs, Gerald F. ; Lü, Junxuan. / Selenium as a cancer preventive agent. Selenium: Its Molecular Biology and Role in Human Health, Second Edition. Springer US, 2006. pp. 249-264
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Combs, GF & Lü, J 2006, Selenium as a cancer preventive agent. in Selenium: Its Molecular Biology and Role in Human Health, Second Edition. Springer US, pp. 249-264. https://doi.org/10.1007/0-387-33827-6_22

Selenium as a cancer preventive agent. / Combs, Gerald F.; Lü, Junxuan.

Selenium: Its Molecular Biology and Role in Human Health, Second Edition. Springer US, 2006. p. 249-264.

Research output: Chapter in Book/Report/Conference proceedingChapter

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Combs GF, Lü J. Selenium as a cancer preventive agent. In Selenium: Its Molecular Biology and Role in Human Health, Second Edition. Springer US. 2006. p. 249-264 https://doi.org/10.1007/0-387-33827-6_22