Selenium compounds, apoptosis and other types of cell death

An overview for cancer therapy

Carmen Sanmartín, Daniel Plano, Arun Sharma, Juan Antonio Palop

Research output: Contribution to journalReview article

122 Citations (Scopus)

Abstract

Selenium (Se) is an essential trace element involved in different physiological functions of the human body and plays a role in cancer prevention and treatment. Induction of apoptosis is considered an important cellular event that can account for the cancer preventive effects of Se. The mechanisms of Se-induced apoptosis are associated with the chemical forms of Se and their metabolism as well as the type of cancer studied. So, some selenocompounds, such as SeO2 involve the activation of caspase-3 while sodium selenite induces apoptosis in the absence of the activation of caspases. Modulation of mitochondrial functions has been reported to play a key role in the regulation of apoptosis and also to be one of the targets of Se compounds. Other mechanisms for apoptosis induction are the modulation of glutathione and reactive oxygen species levels, which may function as intracellular messengers to regulate signaling pathways, or the regulation of kinase, among others. Emerging evidence indicates the overlaps between the apoptosis and other types of cell death such as autophagy. In this review we report different processes of cell death induced by Se compounds in cancer treatment and prevention.

Original languageEnglish (US)
Pages (from-to)9649-9672
Number of pages24
JournalInternational journal of molecular sciences
Volume13
Issue number8
DOIs
StatePublished - Jan 1 2012

Fingerprint

Selenium compounds
selenium compounds
Selenium Compounds
apoptosis
Cell death
death
therapy
Cell Death
cancer
Apoptosis
Selenium
selenium
Neoplasms
induction
Therapeutics
Chemical activation
Modulation
activation
Sodium Selenite
modulation

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Cite this

Sanmartín, Carmen ; Plano, Daniel ; Sharma, Arun ; Palop, Juan Antonio. / Selenium compounds, apoptosis and other types of cell death : An overview for cancer therapy. In: International journal of molecular sciences. 2012 ; Vol. 13, No. 8. pp. 9649-9672.
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Selenium compounds, apoptosis and other types of cell death : An overview for cancer therapy. / Sanmartín, Carmen; Plano, Daniel; Sharma, Arun; Palop, Juan Antonio.

In: International journal of molecular sciences, Vol. 13, No. 8, 01.01.2012, p. 9649-9672.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Selenium compounds, apoptosis and other types of cell death

T2 - An overview for cancer therapy

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AU - Plano, Daniel

AU - Sharma, Arun

AU - Palop, Juan Antonio

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