Selenoprotein gene nomenclature

Brigelius Flohé Regina, Vadim N. Gladyshev, Elias S. Arnér, Marla J. Berry, Elspeth A. Bruford, Raymond F. Burk, Bradley A. Carlson, Sergi Castellano, Laurent Chavatte, Marcus Conrad, Paul R. Copeland, Alan M. Diamond, Donna M. Driscoll, Ana Ferreiro, Leopold Flohé, Fiona R. Green, Roderic Guigó, Diane E. Handy, Dolph L. Hatfield, John Hesketh & 33 others Peter R. Hoffmann, Arne Holmgren, Robert J. Hondal, Michael T. Howard, Kaixun Huang, Hwa Young Kim, Ick Young Kim, Josef Köhrle, Alain Krol, Gregory V. Kryukov, Byeong Jae Lee, Byung Cheon Lee, Xin Gen Lei, Qiong Liu, Alain Lescure, Alexei V. Lobanov, Joseph Loscalzo, Matilde Maiorino, Marco Mariotti, Kumble Sandeep Prabhu, Margaret P. Rayman, Sharon Rozovsky, Gustavo Salinas, Edward E. Schmidt, Lutz Schomburg, Ulrich Schweizer, Miljan Simonović, Roger A. Sunde, Petra A. Tsuji, Susan Tweedie, F. Fulvio Ursini, Philip D. Whanger, Yan Zhang

Research output: Contribution to journalArticle

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Abstract

The human genome contains 25 genes coding for selenocysteine- containing proteins (selenoproteins). These proteins are involved in a variety of functions, most notably redox homeostasis. Selenoprotein enzymes with known functions are designated according to these functions: TXNRD1, TXNRD2, and TXNRD3 (thioredoxin reductases), GPX1, GPX2, GPX3, GPX4, and GPX6 (glutathione peroxidases), DIO1, DIO2, and DIO3 (iodothyronine deiodinases), MSRB1 (methionine sulfoxide reductase B1), and SEPHS2 (selenophosphate synthetase 2). Selenoproteins without known functions have traditionally been denoted by SEL or SEP symbols. However, these symbols are sometimes ambiguous and conflict with the approved nomenclature for several other genes. Therefore, there is a need to implement a rational and coherent nomenclature system for selenoprotein- encoding genes. Our solution is to use the root symbol SELENO followed by a letter. This nomenclature applies to SELENOF (selenoprotein F, the 15-kDa selenoprotein, SEP15), SELENOH (selenoprotein H, SELH, C11orf31), SELENOI (selenoprotein I, SELI, EPT1), SELENOK (selenoprotein K, SELK), SELENOM (selenoprotein M, SELM), SELENON (selenoprotein N, SEPN1, SELN), SELENOO (selenoprotein O, SELO), SELENOP (selenoprotein P, SeP, SEPP1, SELP), SELENOS (selenoprotein S, SELS, SEPS1, VIMP),SELENOT(selenoprotein T, SELT),SELENOV(selenoprotein V, SELV), andSELENOW(selenoprotein W, SELW, SEPW1). This system, approved by the HUGO Gene Nomenclature Committee, also resolves conflicting, missing, and ambiguous designations for selenoprotein genes and is applicable to selenoproteins across vertebrates.

Original languageEnglish (US)
Pages (from-to)24036-24040
Number of pages5
JournalJournal of Biological Chemistry
Volume291
Issue number46
DOIs
StatePublished - Nov 11 2016

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Selenoproteins
Selenocysteine
Terminology
Genes
Proteins
phospholipid-hydroperoxide glutathione peroxidase
Thioredoxin-Disulfide Reductase
Iodide Peroxidase
Gene encoding

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Regina, B. F., Gladyshev, V. N., Arnér, E. S., Berry, M. J., Bruford, E. A., Burk, R. F., ... Zhang, Y. (2016). Selenoprotein gene nomenclature. Journal of Biological Chemistry, 291(46), 24036-24040. https://doi.org/10.1074/jbc.M116.756155
Regina, Brigelius Flohé ; Gladyshev, Vadim N. ; Arnér, Elias S. ; Berry, Marla J. ; Bruford, Elspeth A. ; Burk, Raymond F. ; Carlson, Bradley A. ; Castellano, Sergi ; Chavatte, Laurent ; Conrad, Marcus ; Copeland, Paul R. ; Diamond, Alan M. ; Driscoll, Donna M. ; Ferreiro, Ana ; Flohé, Leopold ; Green, Fiona R. ; Guigó, Roderic ; Handy, Diane E. ; Hatfield, Dolph L. ; Hesketh, John ; Hoffmann, Peter R. ; Holmgren, Arne ; Hondal, Robert J. ; Howard, Michael T. ; Huang, Kaixun ; Kim, Hwa Young ; Kim, Ick Young ; Köhrle, Josef ; Krol, Alain ; Kryukov, Gregory V. ; Lee, Byeong Jae ; Lee, Byung Cheon ; Lei, Xin Gen ; Liu, Qiong ; Lescure, Alain ; Lobanov, Alexei V. ; Loscalzo, Joseph ; Maiorino, Matilde ; Mariotti, Marco ; Prabhu, Kumble Sandeep ; Rayman, Margaret P. ; Rozovsky, Sharon ; Salinas, Gustavo ; Schmidt, Edward E. ; Schomburg, Lutz ; Schweizer, Ulrich ; Simonović, Miljan ; Sunde, Roger A. ; Tsuji, Petra A. ; Tweedie, Susan ; Ursini, F. Fulvio ; Whanger, Philip D. ; Zhang, Yan. / Selenoprotein gene nomenclature. In: Journal of Biological Chemistry. 2016 ; Vol. 291, No. 46. pp. 24036-24040.
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title = "Selenoprotein gene nomenclature",
abstract = "The human genome contains 25 genes coding for selenocysteine- containing proteins (selenoproteins). These proteins are involved in a variety of functions, most notably redox homeostasis. Selenoprotein enzymes with known functions are designated according to these functions: TXNRD1, TXNRD2, and TXNRD3 (thioredoxin reductases), GPX1, GPX2, GPX3, GPX4, and GPX6 (glutathione peroxidases), DIO1, DIO2, and DIO3 (iodothyronine deiodinases), MSRB1 (methionine sulfoxide reductase B1), and SEPHS2 (selenophosphate synthetase 2). Selenoproteins without known functions have traditionally been denoted by SEL or SEP symbols. However, these symbols are sometimes ambiguous and conflict with the approved nomenclature for several other genes. Therefore, there is a need to implement a rational and coherent nomenclature system for selenoprotein- encoding genes. Our solution is to use the root symbol SELENO followed by a letter. This nomenclature applies to SELENOF (selenoprotein F, the 15-kDa selenoprotein, SEP15), SELENOH (selenoprotein H, SELH, C11orf31), SELENOI (selenoprotein I, SELI, EPT1), SELENOK (selenoprotein K, SELK), SELENOM (selenoprotein M, SELM), SELENON (selenoprotein N, SEPN1, SELN), SELENOO (selenoprotein O, SELO), SELENOP (selenoprotein P, SeP, SEPP1, SELP), SELENOS (selenoprotein S, SELS, SEPS1, VIMP),SELENOT(selenoprotein T, SELT),SELENOV(selenoprotein V, SELV), andSELENOW(selenoprotein W, SELW, SEPW1). This system, approved by the HUGO Gene Nomenclature Committee, also resolves conflicting, missing, and ambiguous designations for selenoprotein genes and is applicable to selenoproteins across vertebrates.",
author = "Regina, {Brigelius Floh{\'e}} and Gladyshev, {Vadim N.} and Arn{\'e}r, {Elias S.} and Berry, {Marla J.} and Bruford, {Elspeth A.} and Burk, {Raymond F.} and Carlson, {Bradley A.} and Sergi Castellano and Laurent Chavatte and Marcus Conrad and Copeland, {Paul R.} and Diamond, {Alan M.} and Driscoll, {Donna M.} and Ana Ferreiro and Leopold Floh{\'e} and Green, {Fiona R.} and Roderic Guig{\'o} and Handy, {Diane E.} and Hatfield, {Dolph L.} and John Hesketh and Hoffmann, {Peter R.} and Arne Holmgren and Hondal, {Robert J.} and Howard, {Michael T.} and Kaixun Huang and Kim, {Hwa Young} and Kim, {Ick Young} and Josef K{\"o}hrle and Alain Krol and Kryukov, {Gregory V.} and Lee, {Byeong Jae} and Lee, {Byung Cheon} and Lei, {Xin Gen} and Qiong Liu and Alain Lescure and Lobanov, {Alexei V.} and Joseph Loscalzo and Matilde Maiorino and Marco Mariotti and Prabhu, {Kumble Sandeep} and Rayman, {Margaret P.} and Sharon Rozovsky and Gustavo Salinas and Schmidt, {Edward E.} and Lutz Schomburg and Ulrich Schweizer and Miljan Simonović and Sunde, {Roger A.} and Tsuji, {Petra A.} and Susan Tweedie and Ursini, {F. Fulvio} and Whanger, {Philip D.} and Yan Zhang",
year = "2016",
month = "11",
day = "11",
doi = "10.1074/jbc.M116.756155",
language = "English (US)",
volume = "291",
pages = "24036--24040",
journal = "Journal of Biological Chemistry",
issn = "0021-9258",
publisher = "American Society for Biochemistry and Molecular Biology Inc.",
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Regina, BF, Gladyshev, VN, Arnér, ES, Berry, MJ, Bruford, EA, Burk, RF, Carlson, BA, Castellano, S, Chavatte, L, Conrad, M, Copeland, PR, Diamond, AM, Driscoll, DM, Ferreiro, A, Flohé, L, Green, FR, Guigó, R, Handy, DE, Hatfield, DL, Hesketh, J, Hoffmann, PR, Holmgren, A, Hondal, RJ, Howard, MT, Huang, K, Kim, HY, Kim, IY, Köhrle, J, Krol, A, Kryukov, GV, Lee, BJ, Lee, BC, Lei, XG, Liu, Q, Lescure, A, Lobanov, AV, Loscalzo, J, Maiorino, M, Mariotti, M, Prabhu, KS, Rayman, MP, Rozovsky, S, Salinas, G, Schmidt, EE, Schomburg, L, Schweizer, U, Simonović, M, Sunde, RA, Tsuji, PA, Tweedie, S, Ursini, FF, Whanger, PD & Zhang, Y 2016, 'Selenoprotein gene nomenclature', Journal of Biological Chemistry, vol. 291, no. 46, pp. 24036-24040. https://doi.org/10.1074/jbc.M116.756155

Selenoprotein gene nomenclature. / Regina, Brigelius Flohé; Gladyshev, Vadim N.; Arnér, Elias S.; Berry, Marla J.; Bruford, Elspeth A.; Burk, Raymond F.; Carlson, Bradley A.; Castellano, Sergi; Chavatte, Laurent; Conrad, Marcus; Copeland, Paul R.; Diamond, Alan M.; Driscoll, Donna M.; Ferreiro, Ana; Flohé, Leopold; Green, Fiona R.; Guigó, Roderic; Handy, Diane E.; Hatfield, Dolph L.; Hesketh, John; Hoffmann, Peter R.; Holmgren, Arne; Hondal, Robert J.; Howard, Michael T.; Huang, Kaixun; Kim, Hwa Young; Kim, Ick Young; Köhrle, Josef; Krol, Alain; Kryukov, Gregory V.; Lee, Byeong Jae; Lee, Byung Cheon; Lei, Xin Gen; Liu, Qiong; Lescure, Alain; Lobanov, Alexei V.; Loscalzo, Joseph; Maiorino, Matilde; Mariotti, Marco; Prabhu, Kumble Sandeep; Rayman, Margaret P.; Rozovsky, Sharon; Salinas, Gustavo; Schmidt, Edward E.; Schomburg, Lutz; Schweizer, Ulrich; Simonović, Miljan; Sunde, Roger A.; Tsuji, Petra A.; Tweedie, Susan; Ursini, F. Fulvio; Whanger, Philip D.; Zhang, Yan.

In: Journal of Biological Chemistry, Vol. 291, No. 46, 11.11.2016, p. 24036-24040.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Selenoprotein gene nomenclature

AU - Regina, Brigelius Flohé

AU - Gladyshev, Vadim N.

AU - Arnér, Elias S.

AU - Berry, Marla J.

AU - Bruford, Elspeth A.

AU - Burk, Raymond F.

AU - Carlson, Bradley A.

AU - Castellano, Sergi

AU - Chavatte, Laurent

AU - Conrad, Marcus

AU - Copeland, Paul R.

AU - Diamond, Alan M.

AU - Driscoll, Donna M.

AU - Ferreiro, Ana

AU - Flohé, Leopold

AU - Green, Fiona R.

AU - Guigó, Roderic

AU - Handy, Diane E.

AU - Hatfield, Dolph L.

AU - Hesketh, John

AU - Hoffmann, Peter R.

AU - Holmgren, Arne

AU - Hondal, Robert J.

AU - Howard, Michael T.

AU - Huang, Kaixun

AU - Kim, Hwa Young

AU - Kim, Ick Young

AU - Köhrle, Josef

AU - Krol, Alain

AU - Kryukov, Gregory V.

AU - Lee, Byeong Jae

AU - Lee, Byung Cheon

AU - Lei, Xin Gen

AU - Liu, Qiong

AU - Lescure, Alain

AU - Lobanov, Alexei V.

AU - Loscalzo, Joseph

AU - Maiorino, Matilde

AU - Mariotti, Marco

AU - Prabhu, Kumble Sandeep

AU - Rayman, Margaret P.

AU - Rozovsky, Sharon

AU - Salinas, Gustavo

AU - Schmidt, Edward E.

AU - Schomburg, Lutz

AU - Schweizer, Ulrich

AU - Simonović, Miljan

AU - Sunde, Roger A.

AU - Tsuji, Petra A.

AU - Tweedie, Susan

AU - Ursini, F. Fulvio

AU - Whanger, Philip D.

AU - Zhang, Yan

PY - 2016/11/11

Y1 - 2016/11/11

N2 - The human genome contains 25 genes coding for selenocysteine- containing proteins (selenoproteins). These proteins are involved in a variety of functions, most notably redox homeostasis. Selenoprotein enzymes with known functions are designated according to these functions: TXNRD1, TXNRD2, and TXNRD3 (thioredoxin reductases), GPX1, GPX2, GPX3, GPX4, and GPX6 (glutathione peroxidases), DIO1, DIO2, and DIO3 (iodothyronine deiodinases), MSRB1 (methionine sulfoxide reductase B1), and SEPHS2 (selenophosphate synthetase 2). Selenoproteins without known functions have traditionally been denoted by SEL or SEP symbols. However, these symbols are sometimes ambiguous and conflict with the approved nomenclature for several other genes. Therefore, there is a need to implement a rational and coherent nomenclature system for selenoprotein- encoding genes. Our solution is to use the root symbol SELENO followed by a letter. This nomenclature applies to SELENOF (selenoprotein F, the 15-kDa selenoprotein, SEP15), SELENOH (selenoprotein H, SELH, C11orf31), SELENOI (selenoprotein I, SELI, EPT1), SELENOK (selenoprotein K, SELK), SELENOM (selenoprotein M, SELM), SELENON (selenoprotein N, SEPN1, SELN), SELENOO (selenoprotein O, SELO), SELENOP (selenoprotein P, SeP, SEPP1, SELP), SELENOS (selenoprotein S, SELS, SEPS1, VIMP),SELENOT(selenoprotein T, SELT),SELENOV(selenoprotein V, SELV), andSELENOW(selenoprotein W, SELW, SEPW1). This system, approved by the HUGO Gene Nomenclature Committee, also resolves conflicting, missing, and ambiguous designations for selenoprotein genes and is applicable to selenoproteins across vertebrates.

AB - The human genome contains 25 genes coding for selenocysteine- containing proteins (selenoproteins). These proteins are involved in a variety of functions, most notably redox homeostasis. Selenoprotein enzymes with known functions are designated according to these functions: TXNRD1, TXNRD2, and TXNRD3 (thioredoxin reductases), GPX1, GPX2, GPX3, GPX4, and GPX6 (glutathione peroxidases), DIO1, DIO2, and DIO3 (iodothyronine deiodinases), MSRB1 (methionine sulfoxide reductase B1), and SEPHS2 (selenophosphate synthetase 2). Selenoproteins without known functions have traditionally been denoted by SEL or SEP symbols. However, these symbols are sometimes ambiguous and conflict with the approved nomenclature for several other genes. Therefore, there is a need to implement a rational and coherent nomenclature system for selenoprotein- encoding genes. Our solution is to use the root symbol SELENO followed by a letter. This nomenclature applies to SELENOF (selenoprotein F, the 15-kDa selenoprotein, SEP15), SELENOH (selenoprotein H, SELH, C11orf31), SELENOI (selenoprotein I, SELI, EPT1), SELENOK (selenoprotein K, SELK), SELENOM (selenoprotein M, SELM), SELENON (selenoprotein N, SEPN1, SELN), SELENOO (selenoprotein O, SELO), SELENOP (selenoprotein P, SeP, SEPP1, SELP), SELENOS (selenoprotein S, SELS, SEPS1, VIMP),SELENOT(selenoprotein T, SELT),SELENOV(selenoprotein V, SELV), andSELENOW(selenoprotein W, SELW, SEPW1). This system, approved by the HUGO Gene Nomenclature Committee, also resolves conflicting, missing, and ambiguous designations for selenoprotein genes and is applicable to selenoproteins across vertebrates.

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Regina BF, Gladyshev VN, Arnér ES, Berry MJ, Bruford EA, Burk RF et al. Selenoprotein gene nomenclature. Journal of Biological Chemistry. 2016 Nov 11;291(46):24036-24040. https://doi.org/10.1074/jbc.M116.756155