Selenoproteins and their role in oxidative stress and inflammation

Ujjawal H. Gandhi, Tejo P. Nagaraja, Kumble Sandeep Prabhu

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The discovery of selenocysteine as the 21st amino acid has revolutionized the understanding of the significance of the essential micronutrient selenium in human and animal health. About 25 different selenoproteins have been identified that collectively function to detoxify reactive oxygen and nitrogen species (RONS) and thus aid in maintaining an optimal redox tone as a vital component of the antioxidant defense system of cells. Knowledge about the physiological properties of the redox-sensitive transcription factors like nuclear factor-kappa B (NF-κB) has made it clear that oxidative stress is an important factor that triggers and sustains inflammation in various disease states. Moreover, there is emerging epidemiological data suggesting a positive association between selenium deficiency and the prevalence of diseases such as atherosclerosis, rheumatoid arthritis, viral infections including HIV-AIDS, and cancer, where chronic inflammation forms the underlying basis of the disease. Recent studies in our laboratory have shown that selenoproteins modulate many cellular regulatory pathways that influence the expression of pro- and anti-inflammatory genes. Thus, elucidation of the diverse molecular mechanisms involved in the anti-inflammatory properties of selenium is important to appreciate its role in disease prevention and treatment. This article reviews the current status of knowledge on the biology of selenium with an emphasis on inflammation.

Original languageEnglish (US)
Pages (from-to)65-73
Number of pages9
JournalCurrent Chemical Biology
Volume7
Issue number1
StatePublished - Jun 11 2013

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Selenoproteins
Oxidative stress
Selenium
Oxidative Stress
Inflammation
Oxidation-Reduction
Anti-Inflammatory Agents
Selenocysteine
Deficiency Diseases
Reactive Nitrogen Species
NF-kappa B
Micronutrients
Virus Diseases
Reactive Oxygen Species
Rheumatoid Arthritis
Atherosclerosis
Acquired Immunodeficiency Syndrome
Animals
Transcription Factors
Antioxidants

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Gandhi, Ujjawal H. ; Nagaraja, Tejo P. ; Prabhu, Kumble Sandeep. / Selenoproteins and their role in oxidative stress and inflammation. In: Current Chemical Biology. 2013 ; Vol. 7, No. 1. pp. 65-73.
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Selenoproteins and their role in oxidative stress and inflammation. / Gandhi, Ujjawal H.; Nagaraja, Tejo P.; Prabhu, Kumble Sandeep.

In: Current Chemical Biology, Vol. 7, No. 1, 11.06.2013, p. 65-73.

Research output: Contribution to journalArticle

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