Self-organizing visualization and pattern matching of vectorcardiographic QRS waveforms

Hui Yang, Fabio Leonelli

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

QRS morphology is commonly used in the electrocardiographic diagnosis of ventricular depolarization such as left bundle branch block (LBBB) and ventricular septal infarction. We investigated whether pattern matching of QRS loops in the 3-dimensional vectorcardiogram (VCG) will improve the grouping of patients whose space-time electrical activity akin to each other, thereby assisting in clinical decision making. First, pattern dissimilarity of VCG QRS loops is qualitatively measured and characterized among patients, resulting in a 93×93 distance matrix of patient-to-patient dissimilarity. Each patient is then represented as a node in the network (or a star in the galaxy), but node locations are optimized to preserve the dissimilarity matrix. The optimization is achieved with a self-organizing algorithm that iteratively minimizes the network energy. Experimental results showed that patients’ locations converge as the representation error reaches a stable phase. The convergence is independent of initial locations of network nodes. Most importantly, 93 patients are automatically organized into 3 clusters of healthy control, LBBB, and infarction. Spatial coordinates of nodes (or patients) are evidently novel predictors that can be used in the computer-assisted detection of cardiac disorders. Self-organizing pattern matching is shown to have strong potentials for large-scale unsupervised learning of patient groups.

Original languageEnglish (US)
Pages (from-to)1-9
Number of pages9
JournalComputers in Biology and Medicine
Volume79
DOIs
StatePublished - Dec 1 2016

Fingerprint

Pattern matching
Visualization
Unsupervised learning
Galaxies
Depolarization
Stars
Bundle-Branch Block
Decision making
Infarction
Learning

All Science Journal Classification (ASJC) codes

  • Computer Science Applications
  • Health Informatics

Cite this

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abstract = "QRS morphology is commonly used in the electrocardiographic diagnosis of ventricular depolarization such as left bundle branch block (LBBB) and ventricular septal infarction. We investigated whether pattern matching of QRS loops in the 3-dimensional vectorcardiogram (VCG) will improve the grouping of patients whose space-time electrical activity akin to each other, thereby assisting in clinical decision making. First, pattern dissimilarity of VCG QRS loops is qualitatively measured and characterized among patients, resulting in a 93×93 distance matrix of patient-to-patient dissimilarity. Each patient is then represented as a node in the network (or a star in the galaxy), but node locations are optimized to preserve the dissimilarity matrix. The optimization is achieved with a self-organizing algorithm that iteratively minimizes the network energy. Experimental results showed that patients’ locations converge as the representation error reaches a stable phase. The convergence is independent of initial locations of network nodes. Most importantly, 93 patients are automatically organized into 3 clusters of healthy control, LBBB, and infarction. Spatial coordinates of nodes (or patients) are evidently novel predictors that can be used in the computer-assisted detection of cardiac disorders. Self-organizing pattern matching is shown to have strong potentials for large-scale unsupervised learning of patient groups.",
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Self-organizing visualization and pattern matching of vectorcardiographic QRS waveforms. / Yang, Hui; Leonelli, Fabio.

In: Computers in Biology and Medicine, Vol. 79, 01.12.2016, p. 1-9.

Research output: Contribution to journalArticle

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